NDLI: Zinc oxide nanoflowers make new blood vessels

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Zinc oxide nanoflowers make new blood vessels

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Nanoscale Vol - 4 Issue - 19

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Zinc oxide nanoflowers make new blood vessels

Content Provider	Royal Society of Chemistry (RSC)
Author	Rana, Rohit K. Patra, Chitta Ranjan Murali, Shruthi Chatterjee, Suvro Patra, Sujata Mukherjee, Sudip Barui, Ayan Kumar Pal, Krishnendu Patel, Ajay Kumar Veeriah, Vimal Manna, Joydeb
Copyright Year	2012
Abstract	It is well established that angiogenesis is the process of formation of new capillaries from pre-existing blood vessels. It is a complex process, involving both pro- and anti-angiogenic factors, and plays a significant role in physiological and pathophysiological processes such as embryonic development, atherosclerosis, post-ischemic vascularization of the myocardium, tumor growth and metastasis, rheumatoid arthritis etc. This is the first report of zinc oxide (ZnO) nanoflowers that show significant pro-angiogenic properties (formation of new capillaries from pre-existing blood vessels), observed by in vitro and in vivo angiogenesis assays. The egg yolk angiogenesis assay using ZnO nanoflowers indicates the presence of matured blood vessels formation. Additionally, it helps to promote endothelial cell (EA.hy926 cells) migration in wound healing assays. Formation of reactive oxygen species (ROS), especially hydrogen peroxide (H2O2)—a redox signaling molecule, might be the plausible mechanism for nanoflower-based angiogenesis. Angiogenesis by nanoflowers may provide the basis for the future development of new alternative therapeutic treatment strategies for cardiovascular and ischemic diseases, where angiogenesis plays a significant role.
Starting Page	7861
Ending Page	7869
Page Count	9
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	4
Issue Number	24
Journal	Nanoscale
DOI	10.1039/c2nr32369a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Reactive oxygen species Hydrogen peroxide Cardiac muscle Antioxidants & Redox Signaling Metastasis Endothelium Angiogenesis Ischemia Rheumatoid arthritis Capillary Atherosclerosis Zinc oxide Yolk
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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