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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Patra, Chitta Ranjan Nethi, Susheel Kumar Barui, Ayan Kumar |
| Copyright Year | 2017 |
| Abstract | Angiogenesis is a vital process that deals with the generation of new blood vessels from pre-existing vasculature and is well known to regulate various physiological as well as pathophysiological processes. We demonstrated that zinc oxide nanoflowers (ZONF) exhibited pro-angiogenic properties in endothelial cells through the production of intracellular reactive oxygen species (ROS), especially H2O2 (hydrogen peroxide). The immense importance of angiogenesis in ischemic and cardiovascular diseases highlights an urgent need to comprehend the detailed molecular mechanisms underlying the ZONF induced angiogenesis process. However, the exact mechanism and signaling pathways behind nanoflowers mediated angiogenesis still remain unclear. In the present study, we report that ZONF induce angiogenesis through MAPK/Akt/eNOS mediated nitric oxide formation, which further acts in a cGMP dependent manner. We strongly believe that exploration of the molecular mechanism and signaling pathways of ZONF driven angiogenesis would be helpful for the advancement of alternative and efficient treatment strategies for ischemic and cardiovascular diseases using a nanomedicine approach. |
| Starting Page | 3391 |
| Ending Page | 3403 |
| Page Count | 13 |
| File Format | HTM / HTML PDF |
| ISSN | 2050750X |
| Volume Number | 5 |
| Issue Number | 18 |
| Journal | Journal of Materials Chemistry B |
| DOI | 10.1039/c6tb03323g |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Angiogenesis Zinc oxide Endothelium Reactive oxygen species Hydrogen peroxide Ischemia Mitogen-activated protein kinase Protein kinase B Nitric oxide Cyclic guanosine monophosphate Nanomedicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Medicine Materials Science Biomedical Engineering |
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