NDLI: Enzyme responsive mesoporous silica nanoparticles for targeted tumor therapy in vitro and in vivo

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Inside back cover

Back cover

Nanoscale Vol - 7 Issue - 7

Nanoscale Vol - 7 Issue - 6

Nanoscale Vol - 7 Issue - 5

Enzyme responsive mesoporous silica nanoparticles for targeted tumor therapy in vitro and in vivo

Content Provider	Royal Society of Chemistry (RSC)
Author	Dai, Liangliang Zhou, Jun Zhao, Xiaojing Cai, Kaiyong Ye, Jingya Luo, Zhong Ding, Xingwei Liu, Junjie Li, Jinghua Zhang, Beilu
Copyright Year	2015
Abstract	This study reports a biocompatible controlled drug release system based on mesoporous silica nanoparticles (MSNs) for tumor microenvironment responsive drug delivery. It was fabricated by grafting phenylboronic acid conjugated human serum albumin (PBA-HSA) onto the surfaces of MSNs as a sealing agent, via an intermediate linker of a functional polypeptide, which was composed of two functional units: the polycation cell penetrating peptide (CPP) polyarginine, and matrix metalloproteinase 2 (MMP-2) substrate peptide. A series of characterizations confirmed that the system had been successfully constructed. In vitro tests proved that the anticancer drug loading system could efficiently induce cell apoptosis in vitro. More importantly, the in vivo tumor experiments confirmed that the anticancer loading system could efficiently inhibit tumor growth with minimal side effects.
Starting Page	3614
Ending Page	3626
Page Count	13
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	7
Issue Number	8
Journal	Nanoscale
DOI	10.1039/c5nr00072f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Human serum albumin CPP Drug delivery Matrix metalloproteinase Polyelectrolyte Mesoporous silica Biocompatibility Peptide Drug prohibition law Skin grafting Cell-penetrating peptide Apoptosis
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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