NDLI: Enzyme-responsive mesoporous silica nanoparticles for tumor cells and mitochondria multistage-targeted drug delivery

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Enzyme-responsive mesoporous silica nanoparticles for tumor cells and mitochondria multistage-targeted drug delivery

Content Provider	Scilit
Author	Naz, Safia Wang, Mingyu Han, Yuning Hu, Bin Teng, Liping Zhou, Juan Zhang, Huijie Chen, Jinghua
Copyright Year	2019
Description	Background: Drug delivery systems (DDS) capable of targeting both cell and organelle levels are highly desirable for effective cancer therapy. In this study, we developed a novel enzyme-responsive, multistage-targeted anticancer DDS based on mesoporous silica nanoparticles (MSNs), which possessed both CD44-targeting and mitochondrial-targeting properties. Materials and methods: Triphenylphosphine (TPP), a mitochondria-targeting compound, was grafted onto the surface of MSNs firstly. Then, Doxorubicin (Dox) was encapsulated into the pore of MSNs, followed by capping with tumor-targeting molecules hyaluronic acid (HA) through electrostatic interactions to form the final product consist of Dox loaded, TPP attached, HA capped mesoporous silica nanoparticles (MSN-DPH). Results: Our results suggested that MSN-DPH was preferentially taken up by cancer cells via CD44 receptor-mediated endocytosis. Moreover, MSN-DPH mainly accumulated in mitochondria owing to the mitochondrial-targeting ability of TPP. Degradation of HA by overexpressed HAase facilitated the release of Dox in cancer cells. Thus, MSN-DPH efficiently killed the cancer cells while exhibited much lower cytotoxicity to normal cells. Conclusion: This study demonstrates a promising multistage-targeted DDS for cancer chemotherapy.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497824/pdf https://www.dovepress.com/getfile.php?fileID=49028
Ending Page	2542
Page Count	10
Starting Page	2533
e-ISSN	11782013
DOI	10.2147/ijn.s202210
Journal	International Journal of Nanomedicine
Volume Number	14
Language	English
Publisher	Informa UK Limited
Publisher Date	2019-04-01
Access Restriction	Open
Subject Keyword	Biomaterials Pharmacology and Pharmacy Cancer Therapy Drug Delivery Enzyme-responsive Mesoporous Silica Nanoparticles Multistage-targeting
Content Type	Text
Resource Type	Article

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