NDLI: Multifunctional superparamagnetic iron oxide nanoparticles for combined chemotherapy and hyperthermia cancer treatment

Content Provider	Royal Society of Chemistry (RSC)
Author	Tong, Sheng Bao, Gang Mohindra, Priya Quinto, Christopher A.
Copyright Year	2015
Abstract	Superparamagnetic iron oxide (SPIO) nanoparticles have the potential for use as a multimodal cancer therapy agent due to their ability to carry anticancer drugs and generate localized heat when exposed to an alternating magnetic field, resulting in combined chemotherapy and hyperthermia. To explore this potential, we synthesized SPIOs with a phospholipid-polyethylene glycol (PEG) coating, and loaded Doxorubicin (DOX) with a 30.8% w/w loading capacity when the PEG length is optimized. We found that DOX-loaded SPIOs exhibited a sustained DOX release over 72 hours where the release kinetics could be altered by the PEG length. In contrast, the heating efficiency of the SPIOs showed minimal change with the PEG length. With a core size of 14 nm, the SPIOs could generate sufficient heat to raise the local temperature to 43 °C, sufficient to trigger apoptosis in cancer cells. Further, we found that DOX-loaded SPIOs resulted in cell death comparable to free DOX, and that the combined effect of DOX and SPIO-induced hyperthermia enhanced cancer cell death in vitro. This study demonstrates the potential of using phospholipid-PEG coated SPIOs for chemotherapy–hyperthermia combinatorial cancer treatment with increased efficacy.
Starting Page	12728
Ending Page	12736
Page Count	9
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	7
Issue Number	29
Journal	Nanoscale
DOI	10.1039/c5nr02718g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Chemotherapy Iron oxide Combinatorics Magnetic field Doxorubicin Cancer Hyperthermia therapy Apoptosis
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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