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Multifunctional Nanoparticles Based on Iron Oxide and Gold-198 Designed for Magnetic Hyperthermia and Radionuclide Therapy as a Potential Tool for Combined HER2-Positive Cancer Treatment
| Content Provider | MDPI |
|---|---|
| Author | Micha, ł Żuk Rafa, ł Podgórski Anna, Ruszczyńska Pawe, ł Krysiński Ciach, Tomasz Majkowska-Pilip, Agnieszka Bilewicz, Aleksander |
| Copyright Year | 2022 |
| Description | Iron oxide nanoparticles are commonly used in many medical applications as they can be easily modified, have a high surface-to-volume ratio, and are biocompatible and biodegradable. This study was performed to synthesize nanoparticles designed for multimodal HER2-positive cancer treatment involving radionuclide therapy and magnetic hyperthermia. The magnetic core $(Fe_{3}O_{4}$) was coated with a gold-198 layer creating so-called core-shell nanoparticles. These were then further modified with a bifunctional PEG linker and monoclonal antibody to achieve the targeted therapy. Monoclonal antibody—trastuzumab was used to target specific breast and nipple HER2-positive cancer cells. The nanoparticles measured by transmission electron microscopy were as small as 9 nm. The bioconjugation of trastuzumab was confirmed by two separate methods: thermogravimetric analysis and iodine-131 labeling. Synthesized nanoparticles showed that they are good heat mediators in an alternating magnetic field and exhibit great specific binding and internalization capabilities towards the SKOV-3 (HER2 positive) cancer cell line. Radioactive nanoparticles also exhibit capabilities regarding spheroid degradation without and with the application of magnetic hyperthermia with a greater impact in the case of the latter. Designed radiobioconjugate shows great promise and has great potential for in vivo studies regarding magnetic hyperthermia and radionuclide combined therapy. |
| Starting Page | 1680 |
| e-ISSN | 19994923 |
| DOI | 10.3390/pharmaceutics14081680 |
| Journal | Pharmaceutics |
| Issue Number | 8 |
| Volume Number | 14 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-08-12 |
| Access Restriction | Open |
| Subject Keyword | Pharmaceutics Oncology Nuclear Medicine Magnetic Hyperthermia Targeted Therapy |
| Content Type | Text |
| Resource Type | Article |
