NDLI: Long-circulating PEGylated manganese ferrite nanoparticles for MRI-based molecular imaging

Content Provider	Royal Society of Chemistry (RSC)
Author	Pozo, David Franco, Jaime M. Rivera-Fernández, Sara Leal, Manuel Pernia García-Martín, María Luisa Fuente, Jesús M. de
Copyright Year	2015
Abstract	Magnetic resonance based molecular imaging has emerged as a very promising technique for early detection and treatment of a wide variety of diseases, including cancer, neurodegenerative disorders, and vascular diseases. The limited sensitivity and specificity of conventional MRI are being overcome by the development of a new generation of contrast agents, using nanotechnology approaches, with improved magnetic and biological properties. In particular, for molecular imaging, high specificity, high sensitivity, and long blood circulation times are required. Furthermore, the lack of toxicity and immunogenicity together with low-cost scalable production are also necessary to get them into the clinics. In this work, we describe a facile, robust and cost-effective ligand-exchange method to synthesize dual T1 and T2 MRI contrast agents with long circulation times. These contrast agents are based on manganese ferrite nanoparticles (MNPs) between 6 and 14 nm in size covered by a 3 kDa polyethylene glycol (PEG) shell that leads to a great stability in aqueous media with high crystallinity and magnetization values, thus retaining the magnetic properties of the uncovered MNPs. Moreover, the PEGylated MNPs have shown different relaxivities depending on their size and the magnetic field applied. Thus, the 6 nm PEGylated MNPs are characterized by a low r2/r1 ratio of 4.9 at 1.5 T, hence resulting in good dual T1 and T2 contrast agents under low magnetic fields, whereas the 14 nm MNPs behave as excellent T2 contrast agents under high magnetic fields (r2 = 335.6 mM−1 s−1). The polymer core shell of the PEGylated MNPs minimizes their cytotoxicity, and allows long blood circulation times. This combination of cellular compatibility and excellent T2 and r2/r1 values under low magnetic fields, together with long circulation times, make these nanomaterials very promising contrast agents for molecular imaging.
Starting Page	2050
Ending Page	2059
Page Count	10
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	7
Issue Number	5
Journal	Nanoscale
DOI	10.1039/c4nr05781c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Ferrite core Magnetic resonance imaging Immunogenicity Polyethylene glycol Polymer Cytotoxicity Nanomaterials Nuclear magnetic resonance Nanotechnology Cancer Manganese
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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