NDLI: Large payloads of gold nanoparticles into the polyamine network core of stimuli-responsive PEGylated nanogels for selective and noninvasive cancer photothermal therapy

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Large payloads of gold nanoparticles into the polyamine network core of stimuli-responsive PEGylated nanogels for selective and noninvasive cancer photothermal therapy

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Nanoscale Vol - 2 Issue - 4

Nanoscale Vol - 2 Issue - 3

Nanoscale Vol - 2 Issue - 2

Nanoscale Vol -1

Large payloads of gold nanoparticles into the polyamine network core of stimuli-responsive PEGylated nanogels for selective and noninvasive cancer photothermal therapy

Content Provider	Royal Society of Chemistry (RSC)
Author	Nagasaki, Yukio Matsuishi, Kiyoto Nakamura, Takahito Oishi, Motoi Murotani, Hiroki Jinji, Yuta Tamura, Atsushi
Copyright Year	2010
Abstract	A biocompatible photothermal nanomedicine based on a PEGylated nanogel containing gold nanoparticles (GNPs) in a cross-linked network core of stimuli-responsive poly[2-(N,N-diethylamino)ethyl methacrylate] (PEAMA) gel for cancer photothermal therapy (PTT) was prepared through the reduction of Au(III) ions without any reducing agents. The influence of the reduction conditions, such as pH, temperature, and N/Au ratio (molar ratio of the amino groups in the PEGylated nanogel to the Au(III) ions), on the formation of the GNPs in the stimuli-responsive PEAMA gel core (reducing environment) was also studied. Note that the PEGylated nanogel containing GNPs prepared at pH 6, 60 °C and N/Au = 1 (PEGylated GNG (1)) was found to have the highest GNP-loading capacity with a diameter of about 8 nm, as observed by TEM; viz., about 27 GNPs formed in a single PEAMA gel core. PEGylated GNG (1) showed a remarkable photothermal efficacy (ΔT = 7.7 °C) under irradiation with Ar ion (Ar+) laser (514.5 nm) at a fluence of 39 W cm−2 for 6 min (14 kJ cm−2). Note that PEGylated GNG (1) showed non-cytotoxicity in the absence of irradiation with Ar+ laser (480 μg mL−1: > 90% cell viability), whereas pronounced cytotoxicity (IC50 = 110 μg mL−1) was observed for PEGylated GNG (1) under irradiation with Ar+ laser at a fluence of 26 W cm−2 for 5 min (7.8 kJ cm−2), because of the heat-generation from the GNPs in the cells, which resulted in selective and noninvasive cancer PTT. Thus, PEGylated GNG (1), which has a high GNP-loading capacity, would be a promising nanomedicine for cancer PTT.
Starting Page	739
Ending Page	746
Page Count	8
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	2
Issue Number	5
Journal	Nanoscale
DOI	10.1039/b9nr00329k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Ion Cytotoxicity Molar concentration PTT Transmission electron microscopy Nanogel Laser IC50 Partial thromboplastin time PH Biocompatibility Nanomedicine Cancer
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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