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Harnessing Endogenous Stimuli for Responsive Materials in Theranostics.
| Content Provider | Europe PMC |
|---|---|
| Author | Cook, AlexanderB. Decuzzi, Paolo |
| Copyright Year | 2021 |
| Abstract | Materials that respondto endogenous stimuli are being leveragedto enhance spatiotemporal control in a range of biomedical applicationsfrom drug delivery to diagnostic tools. The design of materials thatundergo morphological or chemical changes in response to specificbiological cues or pathologies will be an important area of researchfor improving efficacies of existing therapies and imaging agents,while also being promising for developing personalized theranosticsystems. Internal stimuli-responsive systems can be engineered acrosslength scales from nanometers to macroscopic and can respond to endogenoussignals such as enzymes, pH, glucose, ATP, hypoxia, redox signals,and nucleic acids by incorporating synthetic bio-inspired moietiesor natural building blocks. This Review will summarize response mechanismsand fabrication strategies used in internal stimuli-responsive materialswith a focus on drug delivery and imaging for a broad range of pathologies,including cancer, diabetes, vascular disorders, inflammation, andmicrobial infections. We will also discuss observed challenges, futureresearch directions, and clinical translation aspects of these responsivematerials. |
| ISSN | 19360851 |
| Journal | ACS Nano |
| Volume Number | 15 |
| PubMed Central reference number | PMC7905878 |
| Issue Number | 2 |
| PubMed reference number | 33555171 |
| e-ISSN | 1936086X |
| DOI | 10.1021/acsnano.0c09115 |
| Language | English |
| Publisher | AmericanChemical Society |
| Publisher Date | 2021-02-08 |
| Access Restriction | Open |
| Rights License | Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). © 2021 TheAuthors. Published by AmericanChemical Society |
| Subject Keyword | materials nanoparticles responsive polymers nanomedicine biological stimuli formulations pH enzymes |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Physics and Astronomy Engineering Materials Science |
