NDLI: Biodegradable cationic polymeric nanocapsules for overcoming multidrug resistance and enabling drug

Content Provider	Royal Society of Chemistry (RSC)
Author	Li, Yukun Lai, Cheng Kee Schwartz, Stanley A. Tzanakakis, Emmanuel S. Law, Wing-Cheung Aalinkeel, Ravikumar Prasad, Paras N. Wu, Jincheng Chen, Chih-Kuang Yu, Yun Mahajan, Supriya Reynolds, Jessica L. Cheng, Chong Nair, Bindukumar
Copyright Year	2014
Abstract	Having unique architectural features, cationic polymeric nanocapsules (NCs) with well-defined covalently stabilized biodegradable structures were generated as potentially universal and safe therapeutic nanocarriers. These NCs were synthesized from allyl-functionalized cationic polylactide (CPLA) by highly efficient UV-induced thiol–ene interfacial cross-linking in transparent miniemulsions. With tunable nanoscopic sizes, negligible cytotoxicity and remarkable degradability, they are able to encapsulate doxorubicin (Dox) with inner cavities and bind interleukin-8 (IL-8) small interfering RNA (siRNA) with cationic shells. The Dox-encapsulated NCs can effectively bypass the P-glycoprotein (Pgp)-mediated multidrug resistance of MCF7/ADR cancer cells, thereby resulting in increased intracellular drug concentration and reduced cell viability. In vitro studies also showed that the NCs loaded with Dox, IL-8 siRNA and both agents can be readily taken up by PC3 prostate cancer cells, resulting in a significant chemotherapeutic effect and/or IL-8 gene silencing.
Starting Page	1567
Ending Page	1572
Page Count	6
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	6
Issue Number	3
Journal	Nanoscale
DOI	10.1039/c3nr04804g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Biodegradation P-glycoprotein Gene MCF-7 Small interfering RNA Cytotoxicity Dox Doxorubicin Prostate cancer Interleukin 8 Multiple drug resistance Cancer
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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Biodegradable Cationic Polymeric Nanocapsules for Overcoming Multidrug Resistance and Enabling Drug-Gene Co-Delivery to Cancer Cells

Increasing the cytotoxicity of doxorubicin in breast cancer MCF-7 cells with multidrug resistance using a mesoporous silica nanoparticle drug delivery system.

A New Chalcone Derivative C49 Reverses Doxorubicin Resistance in MCF-7/DOX Cells by Inhibiting P-Glycoprotein Expression

Alisol F 24 Acetate Enhances Chemosensitivity and Apoptosis of MCF-7/DOX Cells by Inhibiting P-Glycoprotein-Mediated Drug Efflux

Loperamide, an FDA-Approved Antidiarrhea Drug, Effectively Reverses the Resistance of Multidrug Resistant MCF-7/MDR1 Human Breast Cancer Cells to Doxorubicin-Induced Cytotoxicity

Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin.

Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin

Naringenin Enhances the Anti-Tumor Effect of Doxorubicin Through Selectively Inhibiting the Activity of Multidrug Resistance-Associated Proteins (2008)

Increasing the cytotoxicity of doxorubicin in breast cancer MCF-7 cells with multidrug resistance using a mesoporous silica nanoparticle drug delivery system

Biodegradable cationic polymeric nanocapsules for overcoming multidrug resistance and enabling drug–gene co-delivery to cancer cells

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