NDLI: Loperamide, an FDA-Approved Antidiarrhea Drug, Effectively Reverses the Resistance of Multidrug Resistant MCF-7/MDR1 Human Breast Cancer Cells to Doxorubicin-Induced Cytotoxicity

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Loperamide, an FDA-Approved Antidiarrhea Drug, Effectively Reverses the Resistance of Multidrug Resistant MCF-7/MDR1 Human Breast Cancer Cells to Doxorubicin-Induced Cytotoxicity

Content Provider	Scilit
Author	Zhou, Yanfei Sridhar, Rajagopalan Shan, Liang Sha, Wei Gu, Xinbin Sukumar, Saraswati
Copyright Year	2012
Description	Loperamide is an FDA-approved antidiarrhea drug which acts on the μ-opioid receptors in the mesenteric plexus of large intestine and exhibits limited side effects. We hypothesized that loperamide might reverse the multidrug resistance (MDR) of human cancer cells to chemotherapeutic agents. MCF-7/MDR1 cells express high level of MDR1 and are resistant to doxorubicin. We found that loperamide significantly enhanced the cytotoxicity of doxorubicin to MCF-7/MDR1 cells in a dose-dependent manner. In conclusion, loperamide reversed the resistance of MCF-7/MDR1 cells to doxorubicin, suggesting that chemotherapy in combination with loperamide may benefit patients with MDR tumors once applied in clinic.
Related Links	http://europepmc.org/articles/pmc3305793?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305793/pdf https://www.tandfonline.com/doi/pdf/10.3109/07357907.2011.640653
Ending Page	125
Page Count	7
Starting Page	119
ISSN	07357907
e-ISSN	15324192
DOI	10.3109/07357907.2011.640653
Journal	Cancer Investigation
Issue Number	2
Volume Number	30
Language	English
Publisher	Informa UK Limited
Publisher Date	2012-02-02
Access Restriction	Open
Subject Keyword	Journal: Cancer Investigation Oncology Multidrug Resistance Breast Cancer Loperamide Doxorubicin
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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