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Treating colon cancer with a suicide gene delivered by self-assembled cationic MPEG–PCL micelles

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Nanoscale Vol - 4 Issue - 6

Nanoscale Vol - 4 Issue - 5

Nanoscale Vol - 4 Issue - 4

Nanoscale Vol - 4 Issue - 3

Nanoscale Vol -3

Nanoscale Vol -2

Nanoscale Vol -1

Treating colon cancer with a suicide gene delivered by self-assembled cationic MPEG–PCL micelles

Content Provider	Royal Society of Chemistry (RSC)
Author	Gao, Xiang Wang, Pan Huang, MeiJuan Duan, XingMei Chen, LiJuan Wei, YuQuan Qian, ZhiYong Gou, MaLing Men, Ke
Copyright Year	2012
Abstract	Biodegradable cationic micelles show promise for applications in gene delivery. In this article, we used DOTAP to modify monomethoxy poly(ethylene glycol)–poly(ε-caprolactone) (MPEG–PCL, MP) micelles in one step, creating novel cationic self-assembled DOTAP and MPEG–PCL hybrid micelles (DMP). These micelles had a mean particle size of 46 ± 5.6 nm and a zeta potential of 41.8 ± 0.5 mV, and had the capacity to bind DNA. Compared with PEI25K (the gold standard), DMP micelles had higher transfection efficiency and lower cytotoxicity. Moreover, we used DMP to deliver the Survivin-T34A gene (S-T34A, a suicide gene) to treat colon cancer. DMP delivered the Survivin-T34A gene (DMP/S-T34A) and could induce apoptosis in cancer cells, resulting in inhibition of the growth of C-26 colon cancer cells in vitro. An in vivo study indicated that intraperitoneal administration of DMP micelles delivered the Survivin-T34A gene and efficiently inhibited the growth of abdominal metastatic C-26 colon cancer and the malignant ascites. These data suggest that DMP may be a novel gene carrier, and its delivery of the S-T34A gene may have promising applications in the treatment of colon cancer.
Starting Page	2400
Ending Page	2407
Page Count	8
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	4
Issue Number	7
Journal	Nanoscale
DOI	10.1039/c2nr30079f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Ethylene glycol Caprolactone Gold standard Cytotoxicity Dimethyl phthalate Intraperitoneal injection Transfection Gene Zeta potential DNA Ascites Cancer Apoptosis
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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Treating colon cancer with a suicide gene delivered by self-assembled cationic MPEG–PCL micelles

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