NDLI: Detection of protein deposition within latent fingerprints by surface-enhanced Raman spectroscopy imaging

Content Provider	Royal Society of Chemistry (RSC)
Author	Lu, Lehui Li, Zhishi Mao, Zhu Lu, Yong Song, Wei Liu, Xiaojuan Zhao, Bing
Copyright Year	2012
Abstract	The detection of metabolites is very important for the estimation of the health of human beings. Latent fingerprint contains many constituents and specific contaminants, which give much information of the individual, such as health status, drug abuse etc. For a long time, many efforts have been focused on visualizing latent fingerprints, but little attention has been paid to the detection of such substances at the same time. In this article, we have devised a versatile approach for the ultra-sensitive detection and identification of specific biomolecules deposited within fingerprints via a large-area SERS imaging technique. The antibody bound to the Raman probe modified silver nanoparticles enables the binding to specific proteins within the fingerprints to afford high-definition SERS images of the fingerprint pattern. The SERS spectra and images of Raman probes indirectly provide chemical information regarding the given proteins. By taking advantage of the high sensitivity and the capability of SERS technique to obtain abundant vibrational signatures of biomolecules, we have successfully detected minute quantities of protein present within a latent fingerprint. This technique provides a versatile and effective model to detect biomarkers within fingerprints for medical diagnostics, criminal investigation and other fields.
Starting Page	2333
Ending Page	2338
Page Count	6
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	4
Issue Number	7
Journal	Nanoscale
DOI	10.1039/c2nr12030e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Fingerprint SERS High-definition video Protein
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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