NDLI: Small molecule induced poly(A) single strand to self-structure conformational switching: evidence for the prominent role of H-bonding interactions

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Molecular BioSystems Vol - 13 Issue - 4

Molecular BioSystems Vol - 13 Issue - 3

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Small molecule induced poly(A) single strand to self-structure conformational switching: evidence for the prominent role of H-bonding interactions

Content Provider	Royal Society of Chemistry (RSC)
Author	Chatterjee, Sabyasachi Kumar, Gopinatha Suresh
Copyright Year	2017
Abstract	All messenger RNAs (mRNAs) have a polyadenylic acid tail that is added during post transcriptional RNA processing. Investigation of the structure–function and interactions of polyadenylic acid is an important area to target for cancer and related diseases. Jatrorrhizine and coptisine are two important isoquinoline alkaloids that are structurally very similar, differing only in the substituents on the isoquinoline chromophore. Here we demonstrate that these alkaloids differentially induce a self-structure in single stranded poly(A) using absorbance, thermal melting and differential scanning calorimetry experiments. Jatrorrhizine was found to be more effective than coptisine in binding to poly(A) from spectroscopy and calorimetry data. Molecular modeling results suggested the involvement of more H-bonds in the complexation of the former with poly(A). It appears that the presence of substituents on the alkaloid that can form H-bonding interactions with the adenine nucleotides may play a critical role in the binding and structural rearrangement of poly(A) into the self-structure. The atomic force microscopy data directly visualized the poly(A) self-structured network. We propose a plausible mechanism of the small molecule induced self-structure formation in poly(A). The results presented here may help in the design of effective poly(A) targeted molecules for therapeutic use.
Starting Page	1000
Ending Page	1009
Page Count	10
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	13
Issue Number	5
Journal	Molecular BioSystems
DOI	10.1039/c7mb00031f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Differential scanning calorimetry Spectroscopy RNA Critical Role Adenine Alkaloid Coptisine Molecular modelling Atomic-force microscopy Carboxylic acid Jatrorrhizine Isoquinoline Calorimetry Cancer Chromophore
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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