NDLI: Aggregation behavior of novel heptamethine cyanine dyes upon their binding to native and fibrillar lysozyme

Please wait, while we are loading the content...

Stereoselective binding of agonists to the β₂-adrenergic receptor: insights into molecular details and thermodynamics from molecular dynamics simulations

How RNase HI (Escherichia coli) promoted site-selective hydrolysis works on RNA in duplex with carba-LNA and LNA substituted antisense strands in an antisense strategy context?

Inhibition of the MurA enzyme in Fusobacterium nucleatum by potential inhibitors identified through computational and in vitro approaches

A systematic reconstruction and constraint-based analysis of Leishmania donovani metabolic network: identification of potential antileishmanial drug targets

Aggregation behavior of novel heptamethine cyanine dyes upon their binding to native and fibrillar lysozyme

Structural modeling of the AhR:ARNT complex in the bHLH–PASA–PASB region elucidates the key determinants of dimerization

Integrating multiple omics data for the discovery of potential Beclin-1 interactions in breast cancer

Small molecule induced poly(A) single strand to self-structure conformational switching: evidence for the prominent role of H-bonding interactions

A structural bioinformatics investigation on protein–DNA complexes delineates their modes of interaction

An integrated anti-arrhythmic target network of a Chinese medicine compound, Wenxin Keli, revealed by combined machine learning and molecular pathway analysis

An all-atom molecular dynamics study of the anti-interferon signaling of Ebola virus: interaction mechanisms of EBOV VP24 binding to Karyopherin alpha5

Back cover

Molecular BioSystems Vol - 13 Issue - 4

Molecular BioSystems Vol - 13 Issue - 3

Molecular BioSystems Vol - 13 Issue - 2

Molecular BioSystems Vol - 13 Issue - 1

Molecular BioSystems Vol -12

Molecular BioSystems Vol -9

Molecular BioSystems Vol -8

Molecular BioSystems Vol -7

Molecular BioSystems Vol -6

Molecular BioSystems Vol -5

Molecular BioSystems Vol -4

Molecular BioSystems Vol -3

Molecular BioSystems Vol -2

Aggregation behavior of novel heptamethine cyanine dyes upon their binding to native and fibrillar lysozyme

Content Provider	Royal Society of Chemistry (RSC)
Author	Vus, Kateryna Ryzhova, Olga Tarabara, Ulyana Trusova, Valeriya Deligeorgiev, Todor Gorbenko, Galyna Gadjev, Nikolai Kurutos, Atanas
Copyright Year	2017
Abstract	Two newly synthesized symmetrical heptamethine cyanine dyes, AK7-5 and AK7-6, absorbing in the region of low autofluorescence of biological samples, have been tested for their ability to detect proteins aggregated into amyloid fibrils. In aqueous solution these probes possess three absorption bands corresponding to the monomer, dimer and H-aggregate species. The association of the dye with fibrillar lysozyme was followed by the enhancement of the monomer band and the reduction of the H-band. The absorption spectra measured at various fibril concentrations were analyzed in terms of the model allowing for the shift of equilibria between various dye species due to the binding of monomers and dimers of AK7-5 and AK7-6 to amyloid fibrils. The association constants and stoichiometries of the dye–fibril complexation have been evaluated. In contrast to fibrillar lysozyme, the native protein brought about strong J-aggregate formation accompanied by a marked drop in the absorbance of the dye monomer species. Quantum chemical calculations and simple docking studies showed that AK7-5 and AK7-6 monomers can bind to the grooves, running parallel to the fibril axis. Due to their ability to distinguish between the native and fibrillar protein states, the novel cyanines are recommended as complementary to existing amyloid markers.
Starting Page	970
Ending Page	980
Page Count	11
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	13
Issue Number	5
Journal	Molecular BioSystems
DOI	10.1039/c7mb00185a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Dye Computational chemistry Autofluorescence J-aggregate Amyloid Cyanine Monomer Protein dimer Lysozyme Protein Fibril
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

J-Aggregation Formation of Cyanine Dyes

Synthesis and characterization of heptamethine cyanine dyes.

Synthesis and Characterization of Heptamethine Cyanine Dyes

Novel synthetic approach for accessing drug–dye conjugates for targeted tumour therapy

Synthesis and Optical Properties of Near-Infrared meso-Phenyl-Substituted Symmetric Heptamethine Cyanine Dyes

Introduction of various substitutions to the methine bridge of heptamethine cyanine dyes Via substituted dianil linkers.

Lysozyme Amyloid Fibril Structural Variability Dependence on Initial Protein Folding State

Characterization of chiral h and j aggregates of cyanine dyes formed by dna templating using (2001).

Synthesis of Near-Infrared-Absorbing Anionic Heptamethine Cyanine Dyes with Trifluoromethyl Groups.

Aggregation behavior of novel heptamethine cyanine dyes upon their binding to native and fibrillar lysozyme

Similar Documents

J-Aggregation Formation of Cyanine Dyes

Synthesis and characterization of heptamethine cyanine dyes.

Synthesis and Characterization of Heptamethine Cyanine Dyes

Novel synthetic approach for accessing drug–dye conjugates for targeted tumour therapy

Synthesis and Optical Properties of Near-Infrared meso-Phenyl-Substituted Symmetric Heptamethine Cyanine Dyes

Introduction of various substitutions to the methine bridge of heptamethine cyanine dyes Via substituted dianil linkers.

Lysozyme Amyloid Fibril Structural Variability Dependence on Initial Protein Folding State

Characterization of chiral h and j aggregates of cyanine dyes formed by dna templating using (2001).

Synthesis of Near-Infrared-Absorbing Anionic Heptamethine Cyanine Dyes with Trifluoromethyl Groups.

Aggregation behavior of novel heptamethine cyanine dyes upon their binding to native and fibrillar lysozyme