NDLI: Quantitative proteomic characterization of redox-dependent post-translational modifications on protein cysteines

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Molecular BioSystems Vol - 13 Issue - 4

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Quantitative proteomic characterization of redox-dependent post-translational modifications on protein cysteines

Content Provider	Royal Society of Chemistry (RSC)
Author	Duan, Jicheng Gaffrey, Matthew J. Qian, Wei-Jun
Copyright Year	2017
Abstract	Protein thiols play a crucial role in redox signaling, in the regulation of enzymatic activity and protein function, and in maintaining redox homeostasis in living systems. The unique chemical reactivity of the thiol group makes protein cysteines susceptible to reactions with reactive oxygen and nitrogen species that form various reversible and irreversible post-translational modifications (PTMs). The reversible PTMs in particular are major components of redox signaling and are involved in the regulation of various cellular processes under physiological and pathological conditions. The biological significance of these redox PTMs in both healthy and disease states has been increasingly recognized. Herein, we review recent advances in quantitative proteomic approaches for investigating redox PTMs in complex biological systems, including general considerations of sample processing, chemical or affinity enrichment strategies, and quantitative approaches. We also highlight a number of redox proteomic approaches that enable effective profiling of redox PTMs for specific biological applications. Although technical limitations remain, redox proteomics is paving the way to a better understanding of redox signaling and regulation in both healthy and disease states.
Starting Page	816
Ending Page	829
Page Count	14
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	13
Issue Number	5
Journal	Molecular BioSystems
DOI	10.1039/c6mb00861e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Thiol Reactive oxygen species Proteomics Antioxidants & Redox Signaling Redox Homeostasis Nitrogen Protein
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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