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Molecular BioSystems Vol - 8 Issue - 3

Molecular BioSystems Vol - 8 Issue - 2

Molecular BioSystems Vol -7

Molecular BioSystems Vol -6

Molecular BioSystems Vol -5

Molecular BioSystems Vol -4

Molecular BioSystems Vol -3

Molecular BioSystems Vol -2

Proteomic identification of plasma biomarkers in uterine leiomyoma

Content Provider	Royal Society of Chemistry (RSC)
Author	Lin, Chao-Po Chang, Yi-Ping Chen, Yi-Wen Lin, Szu-Ting Chou, Hsiu-Chuan Lee, Ying-Ray Jian, Shiou-Fen Liu, Wen-Hsin Li, Ji-Min Chan, Hong-Lin
Copyright Year	2012
Abstract	Recent progresses in quantitative proteomics have offered opportunities to discover plasma proteins as biomarkers for tracking the progression and for understanding the molecular mechanisms of uterine leiomyomas. In the present study, plasma samples were analyzed by fluorescence two-dimensional differential gel electrophoresis (2D-DIGE) and differentially expressed proteins were identified by matrix assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS). In total, 20 proteins have been firmly identified representing 13 unique gene products. These proteins mainly functioned in transportation (such as apolipoprotein A-I) and coagulation (such as fibrinogen gamma chain). Additionally, our quantitative proteomic approach has identified numerous previous reported plasma markers of uterine leiomyomas such as alpha-1-antitrypsin. On the contrary, we have presented several putative uterine leiomyomas biomarkers including afamin, apolipoprotein A-I, carbonic anhydrase 1, fibrinogen beta chain, fibrinogen gamma chain, gelsolin, hemopexin, leucine-rich alpha-2-glycoprotein, serotransferrin and vitamin D-binding protein which have not been reported and may be associated with the progression and development of the disease. In summary, we report a comprehensive patient-based proteomic approach for the identification of potential plasma biomarkers for uterine leiomyomas. The potential of utilizing these markers for screening and treating uterine leiomyomas warrants further investigations.
Starting Page	1136
Ending Page	1145
Page Count	10
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	8
Issue Number	4
Journal	Molecular BioSystems
DOI	10.1039/c2mb05453a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Fluorescence spectroscopy Fibrinogen beta chain Quantitative proteomics Gel electrophoresis Coagulation Glycoprotein Hemopexin Apolipoprotein Blood plasma Vitamin D-binding protein Fibrinogen gamma chain Gene Carbonic anhydrase Ionization Laser Extracellular matrix Gelsolin Mass spectrometry
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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