NDLI: ITI-H4, as a biomarker in the serum of recurrent pregnancy loss (RPL) patients

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Molecular BioSystems Vol - 7 Issue - 4

Molecular BioSystems Vol - 7 Issue - 3

Molecular BioSystems Vol - 7 Issue - 2

Molecular BioSystems Vol -6

Molecular BioSystems Vol -5

Molecular BioSystems Vol -4

Molecular BioSystems Vol -3

Molecular BioSystems Vol -2

ITI-H4, as a biomarker in the serum of recurrent pregnancy loss (RPL) patients

Content Provider	Royal Society of Chemistry (RSC)
Author	Cha, Dong-Hyun Kim, Myung-Sun Gu, Bon-Hee Baek, Kwang-Hyun Choi, Bum-Chae Song, Sangjin
Copyright Year	2011
Abstract	Recurrent pregnancy loss (RPL) is defined as at least three pregnancy losses in series prior to the 20–28 weeks of pregnancy. There are several etiological factors associated with immunology, anatomy, endocrinology, genetic, infection, chromosomal abnormalities, and environmental factors contributing to the condition. The aim of this study was to identify RPL associated factors in human blood using proteomics. Since it is difficult to obtain tissues or follicular fluids, we used blood samples from normal and RPL patients to conduct a comparative proteomic study. Three RPL blood samples and one cocktailed blood sample from 3 normal women were used. We performed 2-DE and selected spots were analyzed with MALDI-TOF/MS. In the three RPL blood samples, 2-DE analysis revealed 549, 563 and 533 spots to be differentially expressed, respectively. Through a comparative analysis between the control and RPL, 21 spots were shown to be differentially expressed. Of these, 5 proteins were confirmed by Western blot analysis. One of these proteins, ITI-H4 (inter-α trypsin inhibitor-heavy chain 4), was weakly expressed at a molecular weight of 120 kDa, but was highly expressed at a modified molecular weight of 36 kDa in RPL patients. These findings suggest that ITI-H4 expression may be used as a biomarker, which could facilitate the development of novel diagnostic and therapeutic tools.
Starting Page	1430
Ending Page	1440
Page Count	11
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	7
Issue Number	5
Journal	Molecular BioSystems
DOI	10.1039/c0mb00219d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Russian Premier League Western blot Trypsin Biomarker Immunology Ionization Proteomics Anatomy Endocrinology RPL
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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