NDLI: The phenanthridine biguanides efficiently differentiate between dGdC, dAdT and rArU sequences by two independent, sensitive spectroscopic methods

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The phenanthridine biguanides efficiently differentiate between dGdC, dAdT and rArU sequences by two independent, sensitive spectroscopic methods

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Molecular BioSystems Vol - 7 Issue - 4

Molecular BioSystems Vol - 7 Issue - 3

Molecular BioSystems Vol - 7 Issue - 2

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Molecular BioSystems Vol -5

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Molecular BioSystems Vol -2

The phenanthridine biguanides efficiently differentiate between dGdC, dAdT and rArU sequences by two independent, sensitive spectroscopic methods

Content Provider	Royal Society of Chemistry (RSC)
Author	Glavaš-Obrovac, Ljubica Miljanić, Snežana Mišković, Katarina Stojković, Marijana Radić Piantanida, Ivo
Copyright Year	2011
Abstract	At submicromolar concentrations two novel phenanthridine biguanides exhibit distinctly different spectroscopic signals for dGdC and dAdT sequences, respectively, by opposite fluorimetric changes (quenching for dGdC and increase for dAdT) and especially the bis-biguanide derivative gives an opposite ICD response (negative ICD for dGC and strong positive for dAdT). This specific signalling was explained by the ability of compounds to switch the binding mode from intercalation into dGdC to minor groove binding into dAdT sequences. Both compounds bind to rArU by intercalation, yielding different fluorimetric and CD response in comparison to any of aforementioned ds-DNA. Moreover, both compounds revealed significantly higher affinity toward ds-polynucleotides in comparison to previously studied alkylamine- and urea-analogues. Furthermore, DNA/RNA binding properties of novel compounds could be controlled by pH, due to the protonation of heterocyclic nitrogen. Low in vitro cytotoxicity of both compounds against human cell lines makes them interesting spectrophotometric probes.
Starting Page	1753
Ending Page	1765
Page Count	13
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	7
Issue Number	5
Journal	Molecular BioSystems
DOI	10.1039/c1mb05030c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Amine RNA DNA PH International Statistical Classification of Diseases and Related Health Problems Cytotoxicity Phenanthridine Nitrogen Spectrophotometry Heterocyclic compound
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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