NDLI: Potential molecular targets in chemopreventative action of celecoxib: a proteomics analysis of J774.A1 macrophage-like cell line

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Potential molecular targets in chemopreventative action of celecoxib: a proteomics analysis of J774.A1 macrophage-like cell line

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Molecular BioSystems Vol - 7 Issue - 3

Molecular BioSystems Vol - 7 Issue - 2

Molecular BioSystems Vol -6

Molecular BioSystems Vol -5

Molecular BioSystems Vol -4

Molecular BioSystems Vol -3

Molecular BioSystems Vol -2

Potential molecular targets in chemopreventative action of celecoxib: a proteomics analysis of J774.A1 macrophage-like cell line

Content Provider	Royal Society of Chemistry (RSC)
Author	Vaziri, Behrouz Rezaie, Faegheh Salimi, Mona Ghahremani, Mohammad Hossein
Copyright Year	2011
Abstract	The overexpression of cyclooxygenase-2 (COX-2) enzyme has been strongly contributed to tumorigenesis. The efficacy of celecoxib as a selective COX-2 inhibitor has been shown in many studies, but the underlying mechanism as a chemopreventative agent has not yet been well known. For better understanding the chemopreventative molecular mechanisms, we used a comparative proteomics analysis of lipopolysaccharide (LPS) treated and untreated J774.A1 macrophage-like cell lines before and after treatment with celecoxib. Our findings define the contribution of several interesting proteins, including ferritin heavy chain, glyoxalase-1, cofilin, vimentin, and galectin-1, which could extend our understanding of the chemopreventative effects of celecoxib and provide new valuable tools for further anticancer research.
Starting Page	1306
Ending Page	1311
Page Count	6
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	7
Issue Number	4
Journal	Molecular BioSystems
DOI	10.1039/c0mb00201a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Vimentin COX-2 inhibitor Enzyme Ferritin Celecoxib Anticarcinogen Carcinogenesis Galectin Cyclooxygenase Prostaglandin-endoperoxide synthase 2 Proteomics Lipopolysaccharide Cofilin
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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