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Metabolomic anatomy of an animal model revealing homeostatic imbalances in dyslipidaemia

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Molecular BioSystems Vol - 7 Issue - 3

Molecular BioSystems Vol - 7 Issue - 2

Molecular BioSystems Vol -6

Molecular BioSystems Vol -5

Molecular BioSystems Vol -4

Molecular BioSystems Vol -3

Molecular BioSystems Vol -2

Metabolomic anatomy of an animal model revealing homeostatic imbalances in dyslipidaemia

Content Provider	Royal Society of Chemistry (RSC)
Author	Soga, Tomoyoshi Tomita, Masaru Ohashi, Yoshiaki Sato, Hajime Nagashima, Atsushi Ooga, Takushi Sasaki, Kazunori
Copyright Year	2011
Abstract	Metabolomics is an emerging technology that reveals homeostatic imbalances in biological systems. Global determination of metabolite concentrations in body fluid and tissues provides novel anatomical aspects of pathological conditions that cannot be obtained from target-specific measurements. Here, we characterised metabolic imbalance in Watanabe heritable hyperlipidaemic rabbits as a model of hypercholesterolaemia. Using a mass spectrometry-based system, we measured a total of 335 metabolites in plasma and tissues (liver, aorta, cardiac muscle, and brain) from WHHL and healthy control rabbits. From the comparison between two metabolomic profiles, pathophysiological features including glutathione and phosphatidylcholine metabolism indicated the occurrence of oxidative stress in several tissues. Especially for the liver, imbalanced purine catabolism shed light on the transcriptional activation of xanthine oxidase, which is thought to act in absorbing or possibly triggering oxidative stress. We also applied this system to assess the therapeutic effects of simvastatin administration. After the treatment, a portion of the metabolomic features in pathological conditions showed alterations suggesting restoration of metabolism to the healthy condition. These changes were considered to be due to the pleiotropic action of statin, including antioxidant effects, rather than its main inhibitory action on cholesterol biosynthesis.
Starting Page	1217
Ending Page	1223
Page Count	7
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	7
Issue Number	4
Journal	Molecular BioSystems
DOI	10.1039/c0mb00141d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Metabolomics Oxidative stress Body fluid Cardiac muscle Liver Simvastatin Homeostasis Xanthine Statin Metabolism Antioxidant Cholesterol Blood plasma Watanabe Pleiotropy Hypercholesterolemia Phosphatidylcholine Aorta Xanthine oxidase Purine Catabolism WHHL Glutathione
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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Pravastatin Decreases Serum Lipids and Vascular Cholesterol Deposition in Watanabe Heritable Hyperlipidemic (WHHL) Rabbits

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Metabolomic anatomy of an animal model revealing homeostatic imbalances in dyslipidaemia

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