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Metallomics Vol -9

Metallomics Vol -8

Metallomics Vol - 3 Issue - 12

Metallomics Vol - 3 Issue - 9

Metallomics Vol - 3 Issue - 8

Metallomics Vol - 3 Issue - 7

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Inside front cover

Contents list

Metallomics in Japan ( Metallomics Vol - 3 Issue - 7 )

Unique platinum–DNA interactions may lead to more effective platinum-based antitumor drugs

Dynamic action of neurometals at the synapse

Molecular and genetic features of zinc transporters in physiology and pathogenesis

Synthesis and in vitro insulin-mimetic activities of zinc(ii) complexes of ethyl 2,5-dihydro-4-hydroxy-5-oxo-1H-pyrrole-3-carboxylates

Zinc-chelated imidazole groups for DNA polyion complex formation

Effects of Zn(ii) complex with vitamins C and U, and carnitine on metabolic syndrome model rats

Challenge of studies on the development of new Zn complexes (Zn(opt)₂) to treat diabetes mellitus

Roles of copper chaperone for superoxide dismutase 1 and metallothionein in copper homeostasis

Thiol-targeted introduction of selenocysteine to polypeptides for synthesis of glutathione peroxidase mimics

High sensitivity of RBL-2H3 cells to cadmium and manganese: an implication of the role of ZIP8

The presence of mercury selenide in various tissues of the striped dolphin: evidence from μ-XRF-XRD and XAFS analyses

Zinc, copper, and carnosine attenuate neurotoxicity of prion fragment PrP106-126

Equilibrium study on the interaction of phytic acid with polyamines and metal ions

New water-soluble Mn-porphyrin with catalytic activity for superoxide dismutation and peroxynitrite decomposition

Back cover

Metallomics Vol - 3 Issue - 6

Metallomics Vol - 3 Issue - 5

Metallomics Vol - 3 Issue - 4

Metallomics Vol - 3 Issue - 3

Metallomics Vol - 3 Issue - 2

Metallomics Vol -2

Metallomics Vol -1

Dynamic action of neurometals at the synapse

Content Provider	Royal Society of Chemistry (RSC)
Author	Takeda, Atsushi Tamano, Haruna
Copyright Year	2011
Abstract	There are synaptic vesicles that are labeled by Timm's sulfide-silver staining method in the brain, suggesting that synaptic vesicles contain metals such as zinc and copper. Zinc is co-released with glutamate and the importance of zinc signaling in the intracellular compartment, in addition to extracellular compartment, is becoming recognized. Zinc can pass through calcium channels, while blocking them. Calcium signaling plays a critical role for synaptic activity and crosstalk between zinc signaling with calcium signaling through calcium channels may participate in synaptic neurotransmission including synaptic plasticity such as long-term potentiation. Copper released into the synaptic cleft during synaptic excitation may also participate in synaptic neurotransmission. Other metals including copper potentially serve as calcium channel blockers and also influence calcium signaling and zinc signalingvia the interaction with metal-binding proteins such as metallothioneins. Homeostasis of metals needs to be controlled spatiotemporally for proper brain function, and their dyshomeostasis is associated with neurological diseases. However, the data on the dynamic action of metals at synapses is limited and their significance poorly understood. This paper summarizes the action of metals in synaptic neurotransmission focused on calcium signaling at glutamatergic synapses.
Starting Page	656
Ending Page	661
Page Count	6
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	3
Issue Number	7
Journal	Metallomics
DOI	10.1039/c1mt00008j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Calcium signaling Glutamic acid Critical Role Crosstalk Long-term potentiation Homeostasis Glutamate receptor Voltage-dependent calcium channel Zinc Synaptic plasticity Neurotransmitter Chemical synapse Copper
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

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Proposed glucocorticoid-mediated zinc signaling in the hippocampus

Synaptic Zn²⁺ homeostasis and its significance

Calcium / calmodulin-dependent kinase II and long-term potentiation enhance synaptic transmission by the same mechanism ( glutamate receptor / synaptic plasticity / learning )

Dopamine modulation of state-dependent endocannabinoid release and long-term depression in the striatum.

Convergent Metabotropic Signaling Pathways Inhibit SK Channels to Promote Synaptic Plasticity in the Hippocampus

Single Synapse LTP: A Matter of Context?

L-Type Voltage-Gated Ca2+ Channels Regulate Synaptic-Activity-Triggered Recycling Endosome Fusion in Neuronal Dendrites

Cytosolic zinc buffering and muffling: Their role in intracellular zinc homeostasis

Neuron review calcium channel regulation and presynaptic plasticity.

Dynamic action of neurometals at the synapse

Similar Documents

Proposed glucocorticoid-mediated zinc signaling in the hippocampus

Synaptic Zn2+ homeostasis and its significance

Calcium / calmodulin-dependent kinase II and long-term potentiation enhance synaptic transmission by the same mechanism ( glutamate receptor / synaptic plasticity / learning )

Dopamine modulation of state-dependent endocannabinoid release and long-term depression in the striatum.

Convergent Metabotropic Signaling Pathways Inhibit SK Channels to Promote Synaptic Plasticity in the Hippocampus

Single Synapse LTP: A Matter of Context?

L-Type Voltage-Gated Ca2+ Channels Regulate Synaptic-Activity-Triggered Recycling Endosome Fusion in Neuronal Dendrites

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Dynamic action of neurometals at the synapse

Synaptic Zn²⁺ homeostasis and its significance