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Dopamine modulation of state-dependent endocannabinoid release and long-term depression in the striatum.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kreitzer, Anatol C. Malenka, Robert C. |
| Copyright Year | 2005 |
| Abstract | Endocannabinoids are important mediators of short- and long-term synaptic plasticity, but the mechanisms of endocannabinoid release have not been studied extensively outside the hippocampus and cerebellum. Here, we examined the mechanisms of endocannabinoid-mediated long-term depression (eCB-LTD) in the dorsal striatum, a brain region critical for motor control and reinforcement learning. Unlike other cell types, strong depolarization of medium spiny neurons was not sufficient to yield detectable endocannabinoid release. However, when paired with postsynaptic depolarization sufficient to activate L-type calcium channels, activation of postsynaptic metabotropic glutamate receptors (mGluRs), either by high-frequency tetanic stimulation or an agonist, induced eCB-LTD. Pairing bursts of afferent stimulation with brief subthreshold membrane depolarizations that mimicked down-state to up-state transitions also induced eCB-LTD, which not only required activation of mGluRs and L-type calcium channels but also was bidirectionally modulated by dopamine D2 receptors. Consistent with network models, these results demonstrate that dopamine regulates the induction of a Hebbian form of long-term synaptic plasticity in the striatum. However, this gating of plasticity by dopamine is accomplished via an unexpected mechanism involving the regulation of mGluR-dependent endocannabinoid release. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.jneurosci.org/content/jneuro/25/45/10537.full.pdf |
| PubMed reference number | 16280591v1 |
| Volume Number | 25 |
| Issue Number | 45 |
| Journal | The Journal of neuroscience : the official journal of the Society for Neuroscience |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Activation action Calcium Channel Cerebellum Depressive disorder Dopamine D2 Receptor Endocannabinoids Glutamate Receptor Glutamic Acid L-Type Calcium Channels Long-Term Synaptic Depression Neostriatum Neuronal Plasticity Receptors, Metabotropic Glutamate Tissue membrane cell type |
| Content Type | Text |
| Resource Type | Article |
