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| Content Provider | Directory of Open Access Journals (DOAJ) |
|---|---|
| Author | Brian G. Hiester Ashley M. Bourke Brooke L. Sinnen Sarah G. Cook Emily S. Gibson Katharine R. Smith Matthew J. Kennedy |
| Abstract | The repertoire and abundance of proteins displayed on the surface of neuronal dendrites are tuned by regulated fusion of recycling endosomes (REs) with the dendritic plasma membrane. While this process is critical for neuronal function and plasticity, how synaptic activity drives RE fusion remains unexplored. We demonstrate a multistep fusion mechanism that requires Ca2+ from distinct sources. NMDA receptor Ca2+ initiates RE fusion with the plasma membrane, while L-type voltage-gated Ca2+ channels (L-VGCCs) regulate whether fused REs collapse into the membrane or reform without transferring their cargo to the cell surface. Accordingly, NMDA receptor activation triggered AMPA-type glutamate receptor trafficking to the dendritic surface in an L-VGCC-dependent manner. Conversely, potentiating L-VGCCs enhanced AMPA receptor surface expression only when NMDA receptors were also active. Thus L-VGCCs play a role in tuning activity-triggered surface expression of key synaptic proteins by gating the mode of RE fusion. |
| e-ISSN | 22111247 |
| DOI | 10.1016/j.celrep.2017.10.105 |
| Journal | Cell Reports |
| Issue Number | 8 |
| Volume Number | 21 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2017-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Biology (general) Long-term Potentiation Synaptic Plasticity Exocytosis Ampa Receptor Recycling Endosome L-type Voltage-gated Calcium Channel Nmda Receptor Synapse Dendritic Spine Dendrite |
| Content Type | Text |
| Resource Type | Article |
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