NDLI: Exploiting the protein corona around gold nanorods for low-dose combined photothermal and photodynamic therapy

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Journal of Materials Chemistry B Vol -4

Journal of Materials Chemistry B Vol -3

Journal of Materials Chemistry B Vol -2

Journal of Materials Chemistry B Vol -1

Exploiting the protein corona around gold nanorods for low-dose combined photothermal and photodynamic therapy

Content Provider	Royal Society of Chemistry (RSC)
Author	Neo, Dawn Jing Hui Kanchanawong, Pakorn Cheah, Joshua U-Jin Thong, Patricia Soo Ping Yeo, Eugenia Li Ling Soo, Khee Chee Goh, Wah Ing Kah, James Chen Yong
Copyright Year	2017
Abstract	A nanodevice comprising human serum (HS) protein corona coated gold nanorods (NRs) has been developed to perform both photothermal therapy (PTT) and photodynamic therapy (PDT) simultaneously at a very low dose under irradiation by a single laser. Here, we exploit the protein corona to load a photosensitizer, chlorin e6 (Ce6), to form NR-HS-Ce6, whose excitation wavelength matches with the longitudinal surface plasmon resonance (LSPR) of NRs. When excited by a single laser, the NRs caused photothermal ablation of cancer cells while Ce6 simultaneously produced reactive oxygen species (ROS) to kill cancer cells through oxidative stress in PDT. We found that the protein corona did not affect the photothermal heating of NRs and observed more than 5-fold increase in ROS generation when Ce6 was loaded on NR-HS compared to free HS-Ce6 dissolved in HS. The uptake of Ce6 by Cal 27 oral squamous cell carcinoma (OSCC) cells also increased 57-fold when loaded on NR-HS compared to free HS-Ce6. While both PDT and PTT have established modest success in reducing cancer cell viability on their own, we have shown that the combined therapy can achieve near complete eradication (95.2% cell kill) of cancer cells even at an extremely low dose of 50 pM of NR-HS-Ce6 containing an equivalent of 7.67 μg mL−1 Au and 4.83 nM Ce6. This near complete cell kill at such a low dose has not been reported previously. The advantages of this nanoscale delivery system showcase the application of protein corona in cancer treatment instead of considering it as an undesirable biological artefact.
Starting Page	254
Ending Page	268
Page Count	15
File Format	HTM / HTML PDF
ISSN	2050750X
Volume Number	5
Issue Number	2
Journal	Journal of Materials Chemistry B
DOI	10.1039/c6tb02743a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	PTT Nanotechnology Protein Corona discharge Nanorod Partial thromboplastin time Photodynamic therapy Laser Photosensitizer Chlorin Wavelength Surface plasmon Surface plasmon resonance Photothermal therapy Cancer Reactive oxygen species Oxidative stress The UpTake Cal 27 Carcinoma
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Materials Science Biomedical Engineering

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