NDLI: Engineering an aligned endothelial monolayer on a topologically modified nanofibrous platform with a micropatterned structure produced by femtosecond laser ablation

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Journal of Materials Chemistry B Vol -4

Journal of Materials Chemistry B Vol -3

Journal of Materials Chemistry B Vol -2

Journal of Materials Chemistry B Vol -1

Engineering an aligned endothelial monolayer on a topologically modified nanofibrous platform with a micropatterned structure produced by femtosecond laser ablation

Content Provider	Royal Society of Chemistry (RSC)
Author	Shin, Heungsoo Lim, Youn Mook Heo, Yunhoe Chung, Yong-Woo Shin, Hyeok Jun Jun, Indong Jeon, Hojeong Shin, Young Min Kim, Kyeongsoo
Copyright Year	2017
Abstract	A monolayer of endothelial cells (ECs) aligned along the direction of blood flow plays crucial roles in the regulation of anti-thrombogenic and pro-inflammatory reactions in the blood vessel wall. Thus, many researchers have attempted to mimic the aligned structure of ECs in vascular grafts or tissue-engineered blood vessels. In the present study, we fabricated micro-groove patterned nanofibers using a femtosecond laser ablation technique to recapitulate the densely organized anisotropic architecture of the endothelial layer. Femtosecond laser ablation enabled us to generate high-resolution groove patterns (10 μm width) with 20 or 80 μm gaps on randomly oriented electrospun nanofibers. The patterned nanofibers exhibited anisotropic (transverse: 101.1 ± 4.0° and longitudinal: 123.5 ± 9.4°) water contact angles; however, the mechanical properties were consistent in both directions. The micropatterned nanofibers modulated the aligned structure or aspect ratio (20 μm: 0.23 ± 0.11 and 80 μm: 0.42 ± 0.18) of ECs along the pattern direction. In particular, the engineered aligned endothelial layer was effective in eliciting an anti-inflammatory response (approximately 50% greater than that of random or aligned nanofibers), thereby effectively preventing monocyte adhesion following activation by TNF-α treatment. Therefore, micropatterning by laser ablation can be utilized to generate high-resolution microgrooves on various substrates, thereby providing fundamental platforms for vascular tissue engineering.
Starting Page	318
Ending Page	328
Page Count	11
File Format	HTM / HTML PDF
ISSN	2050750X
Volume Number	5
Issue Number	2
Journal	Journal of Materials Chemistry B
DOI	10.1039/c6tb02258h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Endothelium Blood vessel Tissue engineering Femtosecond Laser ablation Anisotropy Micrometre Water contact Photolithography Monocyte Tumor necrosis factor alpha Micropatterning
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Materials Science Biomedical Engineering

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