NDLI: Cellulose nanofiber–titania nanocomposites as potential drug delivery systems for dermal applications

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Back cover

Journal of Materials Chemistry B Vol - 3 Issue - 7

Journal of Materials Chemistry B Vol - 3 Issue - 6

Journal of Materials Chemistry B Vol - 3 Issue - 5

Journal of Materials Chemistry B Vol -2

Journal of Materials Chemistry B Vol -1

Cellulose nanofiber–titania nanocomposites as potential drug delivery systems for dermal applications

Content Provider	Royal Society of Chemistry (RSC)
Author	Agafonov, A. V. Seisenbaeva, G. A. Galkina, O. L. Kessler, V. G. Ivanov, V. K.
Copyright Year	2015
Abstract	In this work, new efficient drug delivery systems based on cellulose nanofiber–titania nanocomposites grafted with three different types of model drugs such as diclofenac sodium, penicillamine-D and phosphomycin were successfully synthesized and displayed distinctly different controlled long-term release profiles. Three different methods of medicine introduction were used to show that various interactions between TiO2 and drug molecules could be used to control the kinetics of long-term drug release. All synthesis reactions were carried out in aqueous media. The morphology, chemical structure and properties of the obtained materials were characterized by SEM, TEM and AFM microscopy, nanoparticle tracking analysis, X-ray diffraction, and TGA analysis. According to FT-IR and UV-Vis spectroscopy data, the titania binds to cellulose nanofibers via formation of ester bonds and to drug molecules via formation of surface complexes. The drug release kinetics was studied in vitro for diclofenac sodium and penicillamine-D spectrophotometrically and for phosphomycin using a radio-labeling analysis with 33P-marked ATP as a model phosphate-anchored biomolecule. The results demonstrated that the obtained nanocomposites could potentially be applied in transdermal drug delivery for anesthetics, analgesics and antibiotics.
Starting Page	1688
Ending Page	1698
Page Count	11
File Format	HTM / HTML PDF
ISSN	2050750X
Volume Number	3
Issue Number	8
Journal	Journal of Materials Chemistry B
DOI	10.1039/c4tb01823k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	SEM Drug delivery Cellulose Diclofenac Transmission electron microscopy Microscopy Nanoparticle tracking analysis X-ray crystallography Fourier-transform infrared spectroscopy Ultraviolet\u2013visible spectroscopy Ester Adenosine triphosphate Biomolecule Transdermal patch
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Materials Science Biomedical Engineering

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