NDLI: A colorimetric and ratiometric fluorescent probe for ClO<sup>−</sup> targeting in mitochondria and its application <i>in vivo</i>

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A colorimetric and ratiometric fluorescent probe for ClO⁻ targeting in mitochondria and its application in vivo

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Back cover

Journal of Materials Chemistry B Vol - 3 Issue - 7

Journal of Materials Chemistry B Vol - 3 Issue - 6

Journal of Materials Chemistry B Vol - 3 Issue - 5

Journal of Materials Chemistry B Vol -2

Journal of Materials Chemistry B Vol -1

A colorimetric and ratiometric fluorescent probe for ClO⁻ targeting in mitochondria and its application in vivo

Content Provider	Royal Society of Chemistry (RSC)
Author	Xiao, Hongde Zhao, Jin Quan, Yiwu Wang, Ruiyong Li, Jianhui Yin, Gui Wang, Jie
Copyright Year	2015
Abstract	A colorimetric and ratiometric fluorescent probe PMN–TPP for imaging mitochondrial ClO− was prepared. The selectivity of PMN–TPP was excellent and the detection would not be influenced by other ROS. The limit of detection (LOD = 3σ/slope) for ClO− was evaluated to be 0.43 μM, suggesting the probe's high sensitivity to ClO−. For the biological applications, PMN–TPP performed well in detecting endogenous HClO in living RAW264.7 macrophage cells. A co-localization study employing Mito Tracker green revealed that PMN–TPP was specifically located in the mitochondria of living RAW264.7 macrophage cells. In the in vivo experiment, a nude mouse with acute inflammation stimulated by lipopolysaccharide (LPS) was employed. After injection of PMN–TPP, the fluorescence signal changed gradually in 30 min and then remained unchanged in the injection region, demonstrating that PMN–TPP could detect the endogenous HClO in living animals.
Starting Page	1633
Ending Page	1638
Page Count	6
File Format	HTM / HTML PDF
ISSN	2050750X
Volume Number	3
Issue Number	8
Journal	Journal of Materials Chemistry B
DOI	10.1039/c4tb02003k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	TPP Hypochlorite Reactive oxygen species Macrophage Mito Domain Mitochondrion Nude mouse Inflammation Lipopolysaccharide Fluorescence
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Materials Science Biomedical Engineering

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