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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Tang, Dandan Guo, Yanfei Liu, Huanhuan Li, Cangxia Zhao, Youliang An, Xiaonan |
| Copyright Year | 2015 |
| Abstract | Thermo-, pH and reduction triggered drug delivery vehicles based on dual-cleavable polymeric micelles were investigated. A comblike copolymer (G3) comprising one disulfide linkage and PEG, PCL and acetal-bridged PCL-b-PNIPAM grafts was controllably synthesized by successive RAFT copolymerization, ring-opening polymerization and adductive reaction. G3 was liable to self-assemble into spherical micelles at 25 °C and toroidal micelles at 37 °C, and the aggregates formed at 37 °C could be further converted into multicompartment micelles (pH 5.3), spherical micelles (DTT) and hyperbranched or necklace-like cylinders (pH 5.3 + DTT) upon external stimuli due to the stimuli-triggered topological transformation and reaggregation of copolymer aggregates. Upon external stimuli, doxorubicin (DOX) loaded G3 and G3/β-CD (co)aggregates could exhibit accelerated drug release kinetics. The apparent release rates varied in the range 0.072–0.403 h−1 (for G3 aggregates) and 0.142–0.458 h−1 (for G3/β-CD coaggregates), revealing that the drug release system bearing host–guest interactions could further extend the ranges of the release rate and cumulative release. Although β-CD and G3 micelles lacked notable cytotoxicity, the cytotoxicity of DOX-loaded (co)aggregates to 4T1 cells was higher than free DOX. CLSM images revealed that DOX-loaded copolymer aggregates may enter cells via endocytosis in a manner of nanocomplexes. Our study can not only extend the potential of stimuli-cleavable copolymers toward biomedical applications but also enrich the family of multi-responsive copolymer aggregates. |
| Starting Page | 3959 |
| Ending Page | 3971 |
| Page Count | 13 |
| File Format | HTM / HTML PDF |
| ISSN | 2050750X |
| Volume Number | 3 |
| Issue Number | 19 |
| Journal | Journal of Materials Chemistry B |
| DOI | 10.1039/c5tb00473j |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | PCL CLSM PH Drug delivery Copolymer Disulfide Ring-opening polymerization Anatomical terms of motion Digital terrestrial television Doxorubicin Cytotoxicity Endocytosis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Medicine Materials Science Biomedical Engineering |
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