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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Piana, S. Riela, S. Lazzara, G. Baiamonte, C. Pizzolanti, G. Massaro, M. Giordano, C. Milioto, S. Colletti, C. G. Cavallaro, G. Noto, R. |
| Copyright Year | 2015 |
| Abstract | Multicavity halloysite nanotube materials were employed as simultaneous carriers for two different natural drugs, silibinin and quercetin, at 6.1% and 2.2% drug loadings, respectively. The materials were obtained by grafting functionalized amphiphilic cyclodextrin onto the HNT external surface. The new materials were characterized by FT-IR spectroscopy, SEM, thermogravimetry, turbidimetry, dynamic light scattering and ζ-potential techniques. The interaction of the two molecules with the carrier was studied by HPLC measurements and fluorescence spectroscopy, respectively. The release of the drugs from HNT–amphiphilic cyclodextrin, at two different pH values, was also investigated by means of UV-vis spectroscopy. Biological assays showed that the new complex exhibits anti-proliferative activity against human anaplastic thyroid cancer cell lines 8505C. Furthermore, fluorescence microscopy was used to evaluate whether the carrier was uptaken into 8505C thyroid cancer cell lines. The successful results revealed that the synthesized multicavity system is a material of suitable size to transport drugs into living cells. |
| Starting Page | 4074 |
| Ending Page | 4081 |
| Page Count | 8 |
| File Format | HTM / HTML PDF |
| ISSN | 2050750X |
| Volume Number | 3 |
| Issue Number | 19 |
| Journal | Journal of Materials Chemistry B |
| DOI | 10.1039/c5tb00564g |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | SEM Halloysite Silibinin Quercetin Skin grafting Amphiphile Cyclodextrin Hà Nội T&T F.C. Fourier-transform infrared spectroscopy Spectroscopy Thermogravimetric analysis Turbidimetry Dynamic light scattering High-performance liquid chromatography Fluorescence spectroscopy PH Ultraviolet\u2013visible spectroscopy Anaplastic thyroid cancer Fluorescence microscope Thyroid cancer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Medicine Materials Science Biomedical Engineering |
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