NDLI: Multicavity halloysite-amphiphilic cyclodextrin hybrids for co-delivery of natural drugs into thyroid cancer cells.

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Multicavity halloysite-amphiphilic cyclodextrin hybrids for co-delivery of natural drugs into thyroid cancer cells.

Content Provider	Semantic Scholar
Author	Massaro, Marina Piana, Stefan Colletti, Carmelo Giuseppe Noto, Renato Riela, Serena Baiamonte, Concetta Giordano, Carla Pizzolanti, Giuseppe Cavallaro, Giuseppe Milioto, Stefana Lazzara, Giuseppe
Copyright Year	2015
Abstract	Multicavity halloysite nanotube materials were employed as simultaneous carriers for two different natural drugs, silibinin and quercetin, at 6.1% and 2.2% drug loadings, respectively. The materials were obtained by grafting functionalized amphiphilic cyclodextrin onto the HNT external surface. The new materials were characterized by FT-IR spectroscopy, SEM, thermogravimetry, turbidimetry, dynamic light scattering and ζ-potential techniques. The interaction of the two molecules with the carrier was studied by HPLC measurements and fluorescence spectroscopy, respectively. The release of the drugs from HNT-amphiphilic cyclodextrin, at two different pH values, was also investigated by means of UV-vis spectroscopy. Biological assays showed that the new complex exhibits anti-proliferative activity against human anaplastic thyroid cancer cell lines 8505C. Furthermore, fluorescence microscopy was used to evaluate whether the carrier was uptaken into 8505C thyroid cancer cell lines. The successful results revealed that the synthesized multicavity system is a material of suitable size to transport drugs into living cells.
Starting Page	4074
Ending Page	4081
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1039/C5TB00564G
PubMed reference number	32262629
Journal	Medline
Volume Number	3
Issue Number	19
Alternate Webpage(s)	https://pubs.rsc.org/en/content/getauthorversionpdf/C5TB00564G
Alternate Webpage(s)	http://www.rsc.org/suppdata/c5/tb/c5tb00564g/c5tb00564g1.pdf
Alternate Webpage(s)	https://core.ac.uk/download/pdf/53301215.pdf
Alternate Webpage(s)	https://doi.org/10.1039/C5TB00564G
Journal	Journal of materials chemistry. B
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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