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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Liu, Ji Jérôme, Christine Pauw-Gillet, Marie-Claire De Elst, Luce Vander Duguet, Etienne Mornet, Stéphane Laurent, Sophie Detrembleur, Christophe Debuigne, Antoine |
| Copyright Year | 2014 |
| Abstract | Reversibly crosslinked (RCL) nanogels made of thermo-responsive poly(vinyl alcohol)-b-poly(N-vinylcaprolactam) copolymers were combined with maghemite nanoparticles and developed as new drug delivery systems (DDS). The crosslinking was formed via boronate/diol bonding from the surface-functionalized superparamagnetic maghemite nanoparticles, endowing the DDS with thermo-, pH- and glucose-responsiveness. The capability to load a hydrophobic drug model Nile red (NR) within the RCL nanogels was evaluated, and stimuli-triggered drug release behaviours under different conditions were tested. Zero premature release behaviour was detected at physiological pH in the absence of glucose, whereas triggered release was observed upon exposure to acidic pH (5.0) and/or in the presence of glucose. In light of the superparamagnetic properties of the maghemite nanoparticles and RCL nanogels, magnetically-induced heating, MR imaging performance, as well as remotely magnetically-triggered drug release under alternating magnetic field (AMF), were investigated. Cytotoxicity against fibroblast-like L929 and human melanoma MEL-5 cell lines was assessed via the MTS assay. In vitro stimuli-triggered release of tamoxifen, a chemotherapeutic drug, was also studied within MEL-5 cell cultures under different conditions. These innovative RCL nanogels, integrating different stimuli-responsive components, hydrophobic chemotherapeutic moieties and also diagnostic agents together via reversible crosslinking, are promising new theranostic platforms. |
| Starting Page | 1009 |
| Ending Page | 1023 |
| Page Count | 15 |
| File Format | HTM / HTML PDF |
| ISSN | 2050750X |
| Volume Number | 2 |
| Issue Number | 8 |
| Journal | Journal of Materials Chemistry B |
| DOI | 10.1039/c3tb21272f |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | RCL MTS MR Vinyl alcohol Maghemite Drug delivery Diol Superparamagnetism PH Hydrophobe Nile Glucose Magnetic resonance imaging Magnetic field Cytotoxicity Melanoma MTT assay Tamoxifen |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Medicine Materials Science Biomedical Engineering |
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