Albumin-loaded thermo/pH dual-responsive nanogels based on sodium alginate and poly (N-vinyl caprolactam).

Content Provider	Europe PMC
Author	Mohammad Gholiha, Hamed Ehsani, Morteza Saeidi, Ardeshir Ghadami, Azam
Abstract	During the past decades, many researchers have tried to encapsulate medicines in biopolymer nanogels as injectable medicines. In the present study, dual-responsive bovine serum albumin (BSA)-loaded nanogels prepared from sodium alginate grafted poly (N-vinyl caprolactam) (PNVCL) have been reported. First, PNVCL-g-sodium alginate (PNVCL-g-Alg) was synthesized through free radical polymerization, and then nanogels were obtained from ionic crosslinking of sodium alginate in the presence of BSA. FTIR spectra showed that PNVCL-g-Alg nanogels were successfully prepared. Turbidimetry and rheometry analyses demonstrated the cloud point temperature near the human body. Particle size was evaluated using FE-SEM and dynamic light scattering and it was found that the size of particles in dry and swollen state are about 30 and 280 nm, respectively. The effect of temperature and pH on BSA release was evaluated. By comparing the drug release behavior, we found that the release of the protein at the temperature above the cloud point is faster than that at the temperature below the cloud point. The pH sensitivity of BSA-loaded PNVCL-g-Alg was evaluated at pH 5.5 and 7.4 and showed that the drug release was faster at acidic pH than at neutral pH.
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ISSN	21940509
Volume Number	12
DOI	10.1007/s40204-022-00211-9
PubMed Central reference number	PMC9958215
Issue Number	1
PubMed reference number	36445685
Journal	Progress in Biomaterials [Prog Biomater]
e-ISSN	21940517
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2022-11-29
Publisher Place	Berlin/Heidelberg
Access Restriction	Open
Rights License	© The Author(s), under exclusive licence to Islamic Azad University 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
Subject Keyword	Thermoresponsive nanogels pH-responsive nanogels Dual-responsive Sodium alginate Poly (N-vinyl caprolactam)
Content Type	Text
Resource Type	Article
Subject	Biomaterials Chemical Engineering