NDLI: Enantioselective chemoenzymatic synthesis of a key segment of neuronal nitric oxide synthase inhibitors and several related 3-aminopyridinylmethyl-4-hydroxypyrrolidines

Please wait, while we are loading the content...

Design of recombinant whole-cell catalysts for double reduction of CC and CO bonds in enals and application in the synthesis of Guerbet alcohols as industrial bulk chemicals for lubricants

Preparation of optically active cycloalkenes bearing all-carbon quaternary stereogenic centres via lipase–oxovanadium combo-catalysed dynamic kinetic resolution

New enzymatic methods for the synthesis of primary α-aminonitriles and unnatural α-amino acids by oxidative cyanation of primary amines with d-amino acid oxidase from porcine kidney

One-pot, two-step cascade synthesis of naturally rare l-erythro (3S,4S) ketoses by coupling a thermostable transaminase and transketolase

Enantioselective chemoenzymatic synthesis of a key segment of neuronal nitric oxide synthase inhibitors and several related 3-aminopyridinylmethyl-4-hydroxypyrrolidines

Enzymatic halocyclization of allenic alcohols and carboxylates: a biocatalytic entry to functionalized O-heterocycles

Amine dehydrogenases: efficient biocatalysts for the reductive amination of carbonyl compounds

New degradation compounds from lignocellulosic biomass pretreatment: routes for formation of potent oligophenolic enzyme inhibitors

Stereoselective amination of racemic sec-alcohols through sequential application of laccases and transaminases

Engineering a thermostable transketolase for arylated substrates

Fully renewable polyesters via polycondensation catalyzed by Thermobifida cellulosilytica cutinase 1: an integrated approach

Biocatalytic stereoinversion of d-para-bromophenylalanine in a one-pot three-enzyme reaction

Biocatalytic access to nonracemic γ-oxo esters via stereoselective reduction using ene-reductases

Expanding the reaction space of aldolases using hydroxypyruvate as a nucleophilic substrate

Highly efficient and selective biocatalytic production of glucosamine from chitin

Inside back cover

Back cover

Green Chemistry Vol - 19 Issue - 1

Green Chemistry Vol -9

Green Chemistry Vol -8

Green Chemistry Vol -7

Green Chemistry Vol -6

Green Chemistry Vol -5

Green Chemistry Vol -4

Green Chemistry Vol -3

Green Chemistry Vol -2

Enantioselective chemoenzymatic synthesis of a key segment of neuronal nitric oxide synthase inhibitors and several related 3-aminopyridinylmethyl-4-hydroxypyrrolidines

Content Provider	Royal Society of Chemistry (RSC)
Author	Villar-Barro, Ángela Gotor, Vicente Brieva, Rosario
Copyright Year	2017
Abstract	The lipase catalyzed resolution of several cis and trans 3-aminopyridinylmethyl-4-hydroxypyrrolidines by acylation or hydrolysis has been studied. Some of these pryrrolidines are precursors in the synthesis of selective nNOS inhibitors; for this purpose, the best result is obtained in the resolution of (±)-trans-5via a CAL-A catalysed acylation. The high enantioselectivity of this process allows one to obtain in high yield the optically pure (3S,4R)-configured product that has the correct configuration to complete the synthesis of nNOS inhibitors. The study described here highlights the effect of structural variations remote from the stereogenic centers of the molecule on the reactivity and enantioselectivity of the enzymatic processes.
Starting Page	436
Ending Page	446
Page Count	11
File Format	HTM / HTML PDF
ISSN	14639262
Volume Number	19
Issue Number	2
Journal	Green Chemistry
DOI	10.1039/c6gc01965j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Lipase Acylation Hydrolysis
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Pollution

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Radiolabeled neuronal nitric oxide synthase inhibitors: synthesis, in vivo evaluation, and primate pet studies.

Synthesis, Pharmacological Study and Modeling of 7-Methoxyindazole and Related Substituted Indazoles as Neuronal Nitric Oxide Synthase Inhibitors

Synthesis and enzymatic evaluation of 2- and 4-aminothiazole-based inhibitors of neuronal nitric oxide synthase

Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors.

A QSAR and molecular modeling study on a series of 3, 4-dihydro-1-isoquinolinamines and thienopyridines acting as nitric oxide synthase inhibitors

L337H Mutant of Rat Neuronal Nitric Oxide Synthase Resembles Human Neuronal Nitric Oxide Synthase toward Inhibitors

Synthesis and lipase-catalysed enantioselective acylation studies on ethyl 4-aryl-3,4-dihydropyrimidin-2(1H)-ones

Improved Synthesis of Chiral Pyrrolidine Inhibitors and Their Binding Properties to Neuronal Nitric Oxide Synthase

Synthesis and Evaluation of Dipeptide Amides Containing Nω-Nitroarginine and D-2, 4-Diaminobutyric Acids as Inhibitors of Neuronal Nitric Oxide Synthase

Enantioselective chemoenzymatic synthesis of a key segment of neuronal nitric oxide synthase inhibitors and several related 3-aminopyridinylmethyl-4-hydroxypyrrolidines

Similar Documents

Radiolabeled neuronal nitric oxide synthase inhibitors: synthesis, in vivo evaluation, and primate pet studies.

Synthesis, Pharmacological Study and Modeling of 7-Methoxyindazole and Related Substituted Indazoles as Neuronal Nitric Oxide Synthase Inhibitors

Synthesis and enzymatic evaluation of 2- and 4-aminothiazole-based inhibitors of neuronal nitric oxide synthase

Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors.

A QSAR and molecular modeling study on a series of 3, 4-dihydro-1-isoquinolinamines and thienopyridines acting as nitric oxide synthase inhibitors

L337H Mutant of Rat Neuronal Nitric Oxide Synthase Resembles Human Neuronal Nitric Oxide Synthase toward Inhibitors

Synthesis and lipase-catalysed enantioselective acylation studies on ethyl 4-aryl-3,4-dihydropyrimidin-2(1H)-ones

Improved Synthesis of Chiral Pyrrolidine Inhibitors and Their Binding Properties to Neuronal Nitric Oxide Synthase

Synthesis and Evaluation of Dipeptide Amides Containing Nω-Nitroarginine and D-2, 4-Diaminobutyric Acids as Inhibitors of Neuronal Nitric Oxide Synthase

Enantioselective chemoenzymatic synthesis of a key segment of neuronal nitric oxide synthase inhibitors and several related 3-aminopyridinylmethyl-4-hydroxypyrrolidines