NDLI: Amine dehydrogenases: efficient biocatalysts for the reductive amination of carbonyl compounds

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Amine dehydrogenases: efficient biocatalysts for the reductive amination of carbonyl compounds

Content Provider	Royal Society of Chemistry (RSC)
Author	Knaus, Tanja Mutti, Francesco G. Böhmer, Wesley
Copyright Year	2017
Abstract	Amines constitute the major targets for the production of a plethora of chemical compounds that have applications in the pharmaceutical, agrochemical and bulk chemical industries. However, the asymmetric synthesis of α-chiral amines with elevated catalytic efficiency and atom economy is still a very challenging synthetic problem. Here, we investigated the biocatalytic reductive amination of carbonyl compounds employing a rising class of enzymes for amine synthesis: amine dehydrogenases (AmDHs). The three AmDHs from this study – operating in tandem with a formate dehydrogenase from Candida boidinii (Cb-FDH) for the recycling of the nicotinamide coenzyme – performed the efficient amination of a range of diverse aromatic and aliphatic ketones and aldehydes with up to quantitative conversion and elevated turnover numbers (TONs). Moreover, the reductive amination of prochiral ketones proceeded with perfect stereoselectivity, always affording the (R)-configured amines with more than 99% enantiomeric excess. The most suitable amine dehydrogenase, the optimised catalyst loading and the required reaction time were determined for each substrate. The biocatalytic reductive amination with this dual-enzyme system (AmDH–Cb-FDH) possesses elevated atom efficiency as it utilizes the ammonium formate buffer as the source of both nitrogen and reducing equivalents. Inorganic carbonate is the sole by-product.
Starting Page	453
Ending Page	463
Page Count	11
File Format	HTM / HTML PDF
ISSN	14639262
Volume Number	19
Issue Number	2
Journal	Green Chemistry
DOI	10.1039/c6gc01987k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	AmDH Candida Agrochemical Enantioselective synthesis Atom economy Reductive amination Carbonyl group Formate dehydrogenase Candida albicans Nicotinamide Cofactor (biochemistry) Aliphatic compound Prochirality Stereoselectivity Enantiomeric excess Amine dehydrogenase Ammonia Formic acid Nitrogen
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Pollution

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Amine dehydrogenases: efficient biocatalysts for the reductive amination of carbonyl compounds

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