NDLI: <i>In vitro</i> antioxidant activities and anti-proliferative properties of the functional herb <i>Abrus cantoniensis</i> and its main alkaloid abrine

Content Provider	Royal Society of Chemistry (RSC)
Author	Zaharna, Mazen Al Li, Li Yang, Mei Chen, Yu-Shan Cheung, Hon-Yeung
Copyright Year	2014
Abstract	Abrus cantoniensis is a common and popular vegetative food consumed as beverage, soup and folk medicine in the tropical and subtropical areas of Asia. It has been claimed valuable for cleansing toxicants in the liver. However, the functional effects of A. cantoniensis have not yet been scientifically explored. This study comprehensively evaluated the in vitro antioxidant and anti-proliferative capacities of the herbal extract and the main alkaloid abrine. Abrine was qualitatively and quantitatively determined in methanol extract (ME) using HPLC-DAD and LC-MS/MS. The results showed that ME, ethyl acetate fraction (EF) and abrine exhibited comparable ABTS radical cation scavenging activities and reducing power to two commercial antioxidants (BHT and Trolox). The EF exerted strong cellular antioxidant activity and selective cytotoxicity against three cancer cell lines in a dose-dependent manner. Biological assays revealed that the EF induced cell cycle arrest at G2/M and apoptosis in MCF-7 and Hep3B cells after 48 h of treatment. Thus, A. cantoniensis exerted potent cellular antioxidant and anti-proliferative properties, highlighting why it has been traditionally used as a functional food.
Starting Page	2268
Ending Page	2277
Page Count	10
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	5
Issue Number	9
Journal	Food & Function
DOI	10.1039/c4fo00217b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Asia Abrus Soup Traditional medicine Liver Antioxidant Alkaloid Methanol Ethyl acetate ABTS Ion Trolox Cytotoxicity Cancer Cell cycle Apoptosis MCF-7 Functional food
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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