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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Wu, Hongxi Du, Lei Xie, Jingli Wu, Yanling Wei, Dongzhi Liu, Yalan Guo, Mingrong Fang, Ming |
| Copyright Year | 2014 |
| Abstract | Recent studies have investigated anti-hypertensive peptides derived from natural food products. In this work, we focus on Phascolosoma esculenta as a resource of anti-hypertensive peptides, which is also a seafood with high nutritive value. Compared with FAO/WHO requirements, P. esculenta was confirmed to contain high contents of amino acids and minerals. To investigate the anti-hypertensive activity of P. esculenta, water-soluble and insoluble proteins were extracted and hydrolysed by pepsin and trypsin, respectively. The hydrolysates of water-soluble proteins derived by pepsin and pepsin–trypsin exhibited angiotensin-converting enzyme (ACE) inhibitory activity with IC50 values of 0.67 and 0.24 mg ml−1, respectively, and those of water-insoluble proteins presented IC50 values of 0.4 and 0.1 mg ml−1, respectively. Experiments on ‘spontaneously hypertensive rats’ (SHRs) were carried out to test the anti-hypertension activity in vivo, which confirmed that the hydrolysates played a significant role in reducing both diastolic blood pressure (DBP) and systolic blood pressure (SBP). Consistently, the in vivo anti-hypertensive activity of the hydrolysis products of pepsin and trypsin used together was also higher than that by using pepsin hydrolysis products alone. As stated in both sets of results, we believe that P. esculenta is an excellent resource of antihypertensive peptides and warrants further investigation. |
| Starting Page | 2317 |
| Ending Page | 2323 |
| Page Count | 7 |
| File Format | HTM / HTML PDF |
| ISSN | 20426496 |
| Volume Number | 5 |
| Issue Number | 9 |
| Journal | Food & Function |
| DOI | 10.1039/c4fo00416g |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Colocasia esculenta Food and Agriculture Organization Pepsin Trypsin Angiotensin-converting enzyme IC50 Blood pressure Hydrolysis Hypertension |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Food Science |
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