NDLI: Gastrointestinal absorption, antiproliferative and anti-inflammatory effect of the major carotenoids of <i>Gardenia jasminoides</i> Ellis on cancer cells

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Food & Function Vol - 8 Issue - 3

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Gastrointestinal absorption, antiproliferative and anti-inflammatory effect of the major carotenoids of Gardenia jasminoides Ellis on cancer cells

Content Provider	Royal Society of Chemistry (RSC)
Author	Fernandes, Iva Oliveira, Hélder Freitas, Victor de Zhang, Qian Cai, Xiaoshuang Mateus, Nuno He, Jingren
Copyright Year	2017
Abstract	The gastrointestinal absorption of the main carotenoids present in Gardenia jasminoides Ellis, crocetin, crocin-1 and crocin-2, was assayed through transport studies on MKN-28 and Caco-2 cell lines. Overall, crocetin was the compound that presented the highest gastrointestinal transport efficiency. Additionally, and since after absorption crocins are metabolized into crocetin, the antiproliferative capacity of crocetin was assayed in MKN-28 (stomach), MCF-7 (breast) and Caco-2 (colon) cancer cell lines. The results point to an antiproliferative effect of crocetin on the three cell lines tested. Anti-inflammatory properties were also assayed. Overall, crocetin showed a potential involvement in the downregulation of IL-1β and TNF-α but not IL-6. Altogether, these results suggest that these compounds can have an important role against cancer proliferation, highlighting the importance of Gardenia jasminoides Ellis as a nutraceutical food source.
Starting Page	1672
Ending Page	1679
Page Count	8
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	8
Issue Number	4
Journal	Food & Function
DOI	10.1039/c7fo00091j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Ellis Gardenia Gardenia jasminoides Crocetin Crocin Caco-2 MCF-7 Large intestine Cancer Interleukin 1 beta Tumor necrosis factor alpha Interleukin 6 Nutraceutical
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Genome-Wide Characterization and Analysis of bHLH Transcription Factors Related to Crocin Biosynthesis in Gardenia jasminoides Ellis (Rubiaceae)

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Gastrointestinal absorption, antiproliferative and anti-inflammatory effect of the major carotenoids of Gardenia jasminoides Ellis on cancer cells

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