NDLI: Structural characterization and anti-aging activity of a novel extracellular polysaccharide from fungus <i>Phellinus</i> sp. in a mammalian system

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Structural characterization and anti-aging activity of a novel extracellular polysaccharide from fungus Phellinus sp. in a mammalian system

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Structural characterization and anti-aging activity of a novel extracellular polysaccharide from fungus Phellinus sp. in a mammalian system

Content Provider	Royal Society of Chemistry (RSC)
Author	Peterson, Eric Charles Li, Dan yang Ma, Xiao-kui Guo, Dan dan Dun, Ying
Copyright Year	2016
Abstract	Little is known about the chemical structure of purified extracellular polysaccharides from Phellinus sp., a fungal species with known medicinal properties. A combination of IR spectroscopy, methylation analysis and NMR were performed for the structural analysis of a purified extracellular polysaccharide derived from Phellinus sp. culture, denoted as SHP-1, along with an evaluation of the anti-aging effect in vivo of the polysaccharide supplementation. The structure of SHP-1 was established, with a backbone composed of →2,4)-α-D-glucopyranose-(1→ and →2)-β-D-mannopyranose-(1→ and two terminal glucopyranose branches. Biochemical analysis from mammalian animal experiments demonstrated that SHP-1 possesses the ability to enhance antioxidant enzyme activities, such as catalase (CAT) and superoxide dismutase (SOD) activities, Trolox equivalent antioxidant capacity (TEAC) in serum of D-galactose-aged mice, while reducing lipofuscin levels, another indicator of cell aging, indicating a potential association with anti-aging activities in a dose dependent manner. This compound had a favourable influence on immune organ indices, and a marked amelioration ability of histopathological hepatic lesions such as necrosis, karyolysis and reduced inflammation and apoptosis in mouse hepatocytes. These results suggest that SHP-1 has strong antioxidant activities and a significant protective effect against oxidative stress or hepatotoxicity induced by D-galactose in mice and it could be developed as a food ingredient or a pharmaceutical to prevent many age-associated diseases such as major depressive disorder and hepatotoxicity. To our knowledge, this is the first report on the antioxidant effects of a novel purified exopolysaccharide derived from Phellinus sp.
Starting Page	3468
Ending Page	3479
Page Count	12
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	7
Issue Number	8
Journal	Food & Function
DOI	10.1039/c6fo00422a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	TEAC Phellinus Infrared spectroscopy Methylation Nuclear magnetic resonance Polysaccharide PTPN6 Glucose Antioxidant Enzyme Catalase Superoxide dismutase Trolox equivalent antioxidant capacity TEAC Corporation Lipofuscin Necrosis Karyolysis Inflammation Apoptosis Mouse Hepatocyte Oxidative stress Hepatotoxicity Galactose Major depressive disorder Extracellular polymeric substance
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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