NDLI: Structural characterization, molecular modification and hepatoprotective effect of melanin from <i>Lachnum</i> YM226 on acute alcohol-induced liver injury in mice

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Structural characterization, molecular modification and hepatoprotective effect of melanin from Lachnum YM226 on acute alcohol-induced liver injury in mice

Content Provider	Royal Society of Chemistry (RSC)
Author	Li, Jinglei Li, Shenglan Su, Nana Shi, Fang Song, Sheng Ye, Ming
Copyright Year	2016
Abstract	In this paper, the possible structural formula of the intracellular homogeneous melanin of Lachnum YM226 (LM) was concluded based on an elemental assay, ultraviolet–visible spectroscopy (UV–Vis), Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), mass spectrometry (MS) and equivalent series resistance (ESR). Meanwhile, a D-glucosamine melanin derivative (GLM) was also prepared and its cytotoxicity was evaluated using the MTT assay. The hepatoprotective effect of LM and GLM was evaluated in an acute alcohol-induced liver injury model. The results showed that pretreatments with LM and GLM markedly decreased subsequent alcohol elicited acute hepatic oxidative and inflammatory stress via improving the activity of antioxidant enzymes (glutathione (GSH), catalase (CAT), glutathione peroxidase (GPX), and total superoxide dismutase (SOD)), reducing hepatic levels of nuclear transcription factor (NF-κB), cytokines related to its activation (interleukin (IL)-6, tumor necrosis factor (TNF)-α and macrophage chemoattractant protein (MCP)-1) and hepatic activities of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2. The protection properties of alcoholic liver injury of GLM were more obvious than that of LM at the same dose. The present findings recommend that LM and GLM may be used as a prototype for the prevention of alcoholic liver injury.
Starting Page	3617
Ending Page	3627
Page Count	11
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	7
Issue Number	8
Journal	Food & Function
DOI	10.1039/c6fo00333h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	MTT MCP Fourier Structural formula Melanin Lachnum Ultraviolet\u2013visible spectroscopy Infrared spectroscopy Nuclear magnetic resonance Mass spectrometry Equivalent series resistance Glucosamine Cytotoxicity MTT assay Hepatoprotection Liver Antioxidant Glutathione Catalase Glutathione peroxidase Superoxide dismutase Transcription factor NF-κB Tumor necrosis factor alpha Macrophage Chemotaxis Protein Nitric oxide synthase Cyclooxygenase
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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