NDLI: Asiatic acid and maslinic acid protected heart <i>via</i> anti-glycative and anti-coagulatory activities in diabetic mice

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Asiatic acid and maslinic acid protected heart via anti-glycative and anti-coagulatory activities in diabetic mice

Content Provider	Royal Society of Chemistry (RSC)
Author	Hung, Yi-chih Yang, Hui-ting Yin, Mei-chin
Copyright Year	2015
Abstract	The cardiac protective effects of asiatic acid (AA) and maslinic acid (MA) in diabetic mice were examined. These triterpenoids at 0.1 or 0.2% of the diet were supplied to diabetic mice for 12 weeks. The AA or MA treatments decreased plasma glucose and HbA1c levels, and creatine phosphokinase and lactate dehydrogenase activities in diabetic mice (p < 0.05). AA or MA intake increased the amount deposited in the heart which retained the cardiac glutathione content and reduced the production of reactive oxygen species, Nε-(carboxymethyl)-lysine, pentosidine, methylglyoxal, interleukin-6, tumor necrosis factor-alpha and monocyte chemoattractant protein-1 in the hearts of diabetic mice (p < 0.05). AA or MA intake lowered plasma von Willebrand factor and fibrinogen levels, and factor VII activity (p < 0.05), also AA or MA intake maintained circulating antithrombin-III and protein C activities (p < 0.05). AA or MA treatments down-regulated cardiac expression of NADPH oxidase, aldose reductase, nuclear factor kappa B (NF-κB) p65 and p-p38; as well as reserving glyoxalase 1 expression (p < 0.05). These two compounds at only 0.2% lowered cardiac expression of NF-κB p50, p-ERK1/2 and the receptor of the advanced glycation endproduct (p < 0.05). These findings support the conclusion that the supplement of these triterpenoids could protect the heart under diabetic conditions via attenuating glycative injury and coagulatory disorders.
Starting Page	2967
Ending Page	2974
Page Count	8
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	6
Issue Number	9
Journal	Food & Function
DOI	10.1039/c5fo00549c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	NADPH Willebrand Acid Master's degree Blood plasma Glucose Glycated hemoglobin Creatine kinase Lactate dehydrogenase Glutathione Reactive oxygen species Lysine Pentosidine Methylglyoxal Interleukin 6 Tumor necrosis factor alpha Monocyte Chemotaxis Protein Von Willebrand factor Fibrinogen Factor VII Protein C NADPH oxidase Aldose reductase NF-κB NFKB1 Cell surface receptor Advanced glycation end-product
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Asiatic acid and maslinic acid protected heart via anti-glycative and anti-coagulatory activities in diabetic mice