NDLI: Hypolipidemic influence of dietary fenugreek (<i>Trigonella foenum-graecum</i>) seeds and garlic (<i>Allium sativum</i>) in experimental myocardial infarction

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Hypolipidemic influence of dietary fenugreek (Trigonella foenum-graecum) seeds and garlic (Allium sativum) in experimental myocardial infarction

Content Provider	Royal Society of Chemistry (RSC)
Author	Mukthamba, Puttaswamy Srinivasan, Krishnapura
Copyright Year	2015
Abstract	The cardioprotective influence of dietary fibre-rich fenugreek seeds and the well-established hypolipidemic spice garlic was evaluated both individually and in combination in isoproterenol induced myocardial infarcted rats. It was particularly examined whether pretreatment with dietary fenugreek, garlic or fenugreek + garlic would be beneficial under hypercholesterolemic conditions by their influence on the tissue lipid profile. Four groups each of male Wistar rats were maintained on either a basal diet or a high cholesterol diet for 8 weeks. Dietary interventions with fenugreek, garlic and the combination of fenugreek and garlic were made by including 10% fenugreek seed powder, 2% freeze-dried garlic powder, and 10% fenugreek seed powder + 2% garlic powder. At the end of the diet regimen, myocardial infarction was induced with isoproterenol (i.p. 80 mg kg−1) twice at intervals of 12 h. The disturbed activities of cardiac marker enzymes in serum and the heart confirmed isoproterenol induced myocardial infarction. Dietary fenugreek, garlic or fenugreek + garlic was found to ameliorate the pathological changes in heart tissue and lipid abnormalities in serum and the heart, the beneficial effect being higher with the combination of fenugreek and garlic, invariably amounting to an additive effect. The results also indicated that the hypercholesterolemic situation aggravated the myocardial damage during isoproterenol-induced myocardial infarction. This dietary intervention study suggested that the combination of fenugreek seeds and garlic offers a higher beneficial influence in exerting the cardioprotective effect.
Starting Page	3117
Ending Page	3125
Page Count	9
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	6
Issue Number	9
Journal	Food & Function
DOI	10.1039/c5fo00240k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Fenugreek Lipid-lowering agent Garlic Isoprenaline Cardiac muscle Cholesterol Freeze-drying Infarction Cardiac marker
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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