NDLI: Modulation of tissue fatty acids by l-carnitine attenuates metabolic syndrome in diet-induced obese rats

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Food & Function Vol - 6 Issue - 7

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Modulation of tissue fatty acids by l-carnitine attenuates metabolic syndrome in diet-induced obese rats

Content Provider	Royal Society of Chemistry (RSC)
Author	Ward, Leigh C. Panchal, Sunil K. Poudyal, Hemant Brown, Lindsay Waanders, Jennifer
Copyright Year	2015
Abstract	Obesity and dyslipidaemia are metabolic defects resulting from impaired lipid metabolism. These impairments are associated with the development of cardiovascular disease and non-alcoholic fatty liver disease. Correcting the defects in lipid metabolism may attenuate obesity and dyslipidaemia, and reduce cardiovascular risk and liver damage. L-Carnitine supplementation was used in this study to enhance fatty acid oxidation so as to ameliorate diet-induced disturbances in lipid metabolism. Male Wistar rats (8–9 weeks old) were fed with either corn starch or high-carbohydrate, high-fat diets for 16 weeks. Separate groups were supplemented with L-carnitine (1.2% in food) on either diet for the last 8 weeks of the protocol. High-carbohydrate, high-fat diet-fed rats showed central obesity, dyslipidaemia, hypertension, impaired glucose tolerance, hyperinsulinaemia, cardiovascular remodelling and non-alcoholic fatty liver disease. L-Carnitine supplementation attenuated these high-carbohydrate, high-fat diet-induced changes, together with modifications in lipid metabolism including the inhibition of stearoyl-CoA desaturase-1 activity, reduced storage of short-chain monounsaturated fatty acids in the tissues with decreased linoleic acid content and trans fatty acids stored in retroperitoneal fat. Thus, L-carnitine supplementation attenuated the signs of metabolic syndrome through inhibition of stearoyl-CoA desaturase-1 activity, preferential β-oxidation of some fatty acids and increased storage of saturated fatty acids and relatively inert oleic acid in the tissues.
Starting Page	2496
Ending Page	2506
Page Count	11
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	6
Issue Number	8
Journal	Food & Function
DOI	10.1039/c5fo00480b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Obesity Dyslipidemia Lipid Metabolism Cardiovascular disease Non-alcoholic fatty liver disease Liver Carnitine Fatty acid Corn starch Abdominal obesity Hypertension Impaired glucose tolerance Stearoyl-CoA Acid Retroperitoneal space Fat Syndrome Beta oxidation
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Modulation of tissue fatty acids by l-carnitine attenuates metabolic syndrome in diet-induced obese rats