NDLI: One-step fabrication of core–shell structured alginate–PLGA/PLLA microparticles as a novel drug delivery system for water soluble drugs

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O²-Protected diazeniumdiolate-modified silica nanoparticles for extended nitric oxide release from dental composites

Synthetic hydrogel platform for three-dimensional culture of embryonic stem cell-derived motor neurons

Bioinspired phosphorylcholine containing polymer films with silver nanoparticles combining antifouling and antibacterial properties

Ice recrystallisation inhibition by polyols: comparison of molecular and macromolecular inhibitors and role of hydrophobic units

One-step fabrication of core–shell structured alginate–PLGA/PLLA microparticles as a novel drug delivery system for water soluble drugs

Fibroblasts remodeling of type IV collagen at a biomaterials interface

Microwave-assisted rapid synthesis of poly(glycerol-sebacate) elastomers

Formation and harvesting of thick pancreatic β-cell sheets on a highly O₂-permeable plate modified with poly(N-isopropylacrylamide)

Viscoelastic hydrogels from poly(vinyl alcohol)–Fe(iii) complex

Study on effective extraction of chicken feather keratins and their films for controlling drug release

Concentration dependent neural differentiation and neurite extension of mouse ESC on primary amine-derivatized surfaces

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One-step fabrication of core–shell structured alginate–PLGA/PLLA microparticles as a novel drug delivery system for water soluble drugs

Content Provider	Royal Society of Chemistry (RSC)
Author	Lim, Ming Pin Alan Widjaja, Effendi Lee, Wei Li Loo, Say Chye Joachim
Copyright Year	2013
Abstract	Current focus on particulate drug delivery entails the need for increased drug loading and sustained release of water soluble drugs. Commonly studied biodegradable polyesters, such as poly(lactide-co-glycolide) (PLGA) and poly(L-lactide) (PLLA), are lacking in terms of loading efficiency of these drugs and a stable encapsulation environment for proteins. While hydrogels could enable higher loading of hydrophilic drugs, they are limited in terms of controlled and sustained release. With this in mind, the aim was to develop microparticles with a hydrophilic drug-loaded hydrogel core encapsulated within a biodegradable polyester shell that can improve hydrophilic drug loading, while providing controlled and sustained release. Herein, we report a single step method of fabricating microparticles via a concurrent ionotropic gelation and solvent extraction. Microparticles fabricated possess a core–shell structure of alginate, encapsulated in a shell constructed of either PLGA or PLLA. The cross-sectional morphology of particles was evaluated via scanning electron microscopy, calcium alginate core dissolution, FT-IR microscopy and Raman mapping. The incorporation of alginate within PLGA or PLLA was shown to increase encapsulation efficiency of a model hydrophilic drug metoclopramide HCl (MCA). The findings showed that the shell served as a membrane in controlling the release of drugs. Such gel-core hydrophobic-shell microparticles thus allow for improved loading and release of water soluble drugs.
Starting Page	486
Ending Page	493
Page Count	8
File Format	HTM / HTML PDF
ISSN	20474830
Volume Number	1
Issue Number	5
Journal	Biomaterials Science
DOI	10.1039/c3bm00175j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Biodegradation Polyester Alginic acid MCA Drug delivery MCA Records Fourier-transform infrared spectroscopy Scanning electron microscope Metoclopramide Gel Hydrochloric acid PLGA PLLA Microscopy Calcium alginate Microparticle Raman Hydrophile Liquid\u2013liquid extraction Ligand-gated ion channel
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

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Alginate modified nanostructured calcium carbonate with enhanced delivery efficiency for gene and drug delivery

Calcium-Induced Gelation of Alginic Acid and pH-Sensitive Reswelling of Dried Gels

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Composite core-shell microparticles from microfluidics for synergistic drug delivery

PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application

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Alginate-peptide amphiphile core-shell microparticles as a targeted drug delivery system.

Bioerodable PLGA-Based Microparticles for Producing Sustained-Release Drug Formulations and Strategies for Improving Drug Loading

One-step fabrication of core–shell structured alginate–PLGA/PLLA microparticles as a novel drug delivery system for water soluble drugs

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One-step fabrication of core–shell structured alginate–PLGA/PLLA microparticles as a novel drug delivery system for water soluble drugs