NDLI: Bioinspired phosphorylcholine containing polymer films with silver nanoparticles combining antifouling and antibacterial properties

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O²-Protected diazeniumdiolate-modified silica nanoparticles for extended nitric oxide release from dental composites

Synthetic hydrogel platform for three-dimensional culture of embryonic stem cell-derived motor neurons

Bioinspired phosphorylcholine containing polymer films with silver nanoparticles combining antifouling and antibacterial properties

Ice recrystallisation inhibition by polyols: comparison of molecular and macromolecular inhibitors and role of hydrophobic units

One-step fabrication of core–shell structured alginate–PLGA/PLLA microparticles as a novel drug delivery system for water soluble drugs

Fibroblasts remodeling of type IV collagen at a biomaterials interface

Microwave-assisted rapid synthesis of poly(glycerol-sebacate) elastomers

Formation and harvesting of thick pancreatic β-cell sheets on a highly O₂-permeable plate modified with poly(N-isopropylacrylamide)

Viscoelastic hydrogels from poly(vinyl alcohol)–Fe(iii) complex

Study on effective extraction of chicken feather keratins and their films for controlling drug release

Concentration dependent neural differentiation and neurite extension of mouse ESC on primary amine-derivatized surfaces

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Biomaterials Science Vol - 1 Issue - 4

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Bioinspired phosphorylcholine containing polymer films with silver nanoparticles combining antifouling and antibacterial properties

Content Provider	Royal Society of Chemistry (RSC)
Author	Ritz, Sandra Fuchs, Adrian V. Pütz, Sabine Landfester, Katharina Mailänder, Volker Ziener, Ulrich
Copyright Year	2013
Abstract	The antibacterial (bioactive) and antifouling (biopassive) properties of stable, uniform, high surface coverage films of poly(hydroxyethyl methacrylate-co-2-methacryloyloxyethyl phosphorylcholine) (p(HEMA-co-MPC)) with embedded, non-leaching silver nanoparticles (AgNPs) are reported. Based on the experimental findings, a mechanism of action of AgNPs in antibacterial activity in combination with antifouling characteristics is discussed. Long-term antifouling studies of E. coli determine little to no adhesion on p(HEMA-co-MPC)/Ag films at 2.5 × 106 CFU mL−1 for 7 d, measured using live/dead staining assays. Agar diffusion tests indicate that there is no leaching of Ag from the films and SEM and EDX analyses of the films before and after incubation with E. coli show no attachment of E. coli and no visible change in film morphology or AgNP dispersal. Antibacterial studies are investigated using E. coli K-12 as a model bacterial strain and are tested in static (CFUs) and dynamic contact assays. Antibacterial efficacy of the films containing extremely low AgNP concentration (3.8 ng cm−2) is shown with growth suppression of E. coli in culture medium for 4 h at 1.35 × 105 CFU mL−1 and killing greater than 99% of E. coli in only 1 h of exposure to concentrations up to 1 × 105 CFU mL−1. These hybrid films may propose an exciting direction to long-term antibacterial and antifouling films in clinical applications.
Starting Page	470
Ending Page	477
Page Count	8
File Format	HTM / HTML PDF
ISSN	20474830
Volume Number	1
Issue Number	5
Journal	Biomaterials Science
DOI	10.1039/c2bm00155a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Escherichia coli Escherichia coli in molecular biology Agar Coli Death Diffusion
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

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Optical, structural and antibacterial properties of silver nanoparticles and DNA-templated silver nanoclusters.

Silver-containing mesoporous bioactive glass with improved antibacterial properties

Antibacterial activities of gold and silver nanoparticles against Escherichia coli and bacillus Calmette-Guérin

Bioinspired phosphorylcholine containing polymer films with silver nanoparticles combining antifouling and antibacterial properties

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Bioinspired phosphorylcholine containing polymer films with silver nanoparticles combining antifouling and antibacterial properties