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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Sun, Qihang Kirk, Edward A. Van Murdoch, William J. Zhang, Bo Ma, Xinpeng Sun, Weilin Radosz, Maciej Jin, Erlei Shen, Youqing Zhou, Zhuxian |
| Copyright Year | 2016 |
| Abstract | An inherent dilemma in the use of nanomedicines for cancer drug delivery is their limited penetration into tumors due to their large size. We have demonstrated that dendrimer/lipid nanoassemblies can solve this problem by means of tumor-triggered disassembly and the release of small (several nanometers) dendrimers to facilitate tumor penetration. Herein, we report a general strategy for the fabrication of nanoassemblies from hydrophobic and hydrophilic dendrimers with phospholipids. Hydrophobic dendrimers could assemble with lipids via hydrophobic interactions, whereas hydrophilic dendrimers could only assemble with lipids in the presence of anionic surfactants via both electrostatic and hydrophobic interactions. The nanoassemblies of hydrophobic dendrimers/lipids were found to be capable of stripping off their lipid layers via fusion with the cell membrane and then intracellular or extracellular release of dendrimers, whereas the nanoassemblies of hydrophilic dendrimers/lipids were internalized via endocytosis and then released their dendrimers inside the cells. Therefore, these dendrimer/lipid nanoassemblies could be used for the delivery of different cancer drugs. |
| Starting Page | 958 |
| Ending Page | 969 |
| Page Count | 12 |
| File Format | HTM / HTML PDF |
| ISSN | 20474830 |
| Volume Number | 4 |
| Issue Number | 6 |
| Journal | Biomaterials Science |
| DOI | 10.1039/c6bm00189k |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Dendrimer Endocytosis Cell membrane Drug delivery Hydrophobe Hydrophile Lipid Cancer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Materials Science Biomedical Engineering |
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