NDLI: Nanoparticle hardness controls the internalization pathway for drug delivery

Content Provider	Royal Society of Chemistry (RSC)
Author	Li, Ye Zhang, Xianren Cao, Dapeng
Copyright Year	2015
Abstract	Nanoparticle (NP)-based drug delivery systems offer fundamental advantages over current therapeutic agents that commonly display a longer circulation time, lower toxicity, specific targeted release, and greater bioavailability. For successful NP-based drug delivery it is essential that the drug-carrying nanocarriers can be internalized by the target cells and transported to specific sites, and the inefficient internalization of nanocarriers is often one of the major sources for drug resistance. In this work, we use the dissipative particle dynamics simulation to investigate the effect of NP hardness on their internalization efficiency. Three simplified models of NP platforms for drug delivery, including polymeric NP, liposome and solid NP, are designed here to represent increasing nanocarrier hardness. Simulation results indicate that NP hardness controls the internalization pathway for drug delivery. Rigid NPs can enter the cell by a pathway of endocytosis, whereas for soft NPs the endocytosis process can be inhibited or frustrated due to wrapping-induced shape deformation and non-uniform ligand distribution. Instead, soft NPs tend to find one of three penetration pathways to enter the cell membrane via rearranging their hydrophobic and hydrophilic segments. Finally, we show that the interaction between nanocarriers and drug molecules is also essential for effective drug delivery.
Starting Page	2758
Ending Page	2769
Page Count	12
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	7
Issue Number	6
Journal	Nanoscale
DOI	10.1039/c4nr05575f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	NP Endocytosis Cell membrane Nanoparticle Ligand Dissipative particle dynamics Liposome Drug delivery Bioavailability Hydrophobe Hydrophile Hardness
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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