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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Liu, Bei Hou, Zhiyao Lin, Jun Huang, Shanshan Li, Chunxia Cheng, Ziyong |
| Copyright Year | 2016 |
| Abstract | The near-infrared (NIR) region (700–1100 nm) is the so-called transparency “therapeutic window” for biological applications owing to its deeper tissue penetration and minimal damage to healthy tissues. In recent years, various NIR-based therapeutic and interventional strategies, such as NIR-triggered drug delivery, photothermal therapy (PTT) and photodynamic therapy (PDT), are under research in intensive preclinical and clinical investigations for cancer treatment. The NIR control in these cancer therapy systems is considered crucial to boost local effective tumor suppression while minimizing side effects, resulting in improved therapeutic efficacy. Some researchers even predict the NIR-triggered cancer therapy to be a new and exciting possibility for clinical nanomedicine applications. In this review, the rapid development of NIR light-responsive cancer therapy based on various smartly designed nanocomposites for deep tumor treatments is introduced. In detail, the use of NIR-sensitive materials for chemotherapy, PTT as well as PDT is highlighted, and the associated challenges and potential solutions are discussed. The applications of NIR-sensitive cancer therapy modalities summarized here can highlight their potential use as promising nanoagents for deep tumor therapy. |
| Starting Page | 890 |
| Ending Page | 909 |
| Page Count | 20 |
| File Format | HTM / HTML PDF |
| ISSN | 20474830 |
| Volume Number | 4 |
| Issue Number | 6 |
| Journal | Biomaterials Science |
| DOI | 10.1039/c6bm00076b |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | PTT Chemotherapy Photodynamic therapy Partial thromboplastin time Therapeutic index Drug delivery Nanomedicine Cancer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Materials Science Biomedical Engineering |
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