NDLI: An <i>in vitro</i> evaluation of fibrinogen and gelatin containing cryogels as dermal regeneration scaffolds

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Functional nanomaterials for near-infrared-triggered cancer therapy

From structures to functions: insights into exosomes as promising drug delivery vehicles

Electrospun nanofibers for cancer diagnosis and therapy

Dynamic control of cell adhesion on a stiffness-tunable substrate for analyzing the mechanobiology of collective cell migration

Nitric oxide-generating l-cysteine-grafted graphene film as a blood-contacting biomaterial

Fc-fusion mimetics

Topographical modulation of macrophage phenotype by shrink-film multi-scale wrinkles

Dual stimuli-responsive smart beads that allow “on–off” manipulation of cancer cells

Fabrication of dendrimer-releasing lipidic nanoassembly for cancer drug delivery

Influence of cell size on cellular uptake of gold nanoparticles

Perfluorooctyl bromide traces self-assembled with polymeric nanovesicles for blood pool ultrasound imaging

Simultaneous characterization of protein–material and cell–protein interactions using dynamic QCM-D analysis on SAM surfaces

Dendrimer mediated clustering of bacteria: improved aggregation and evaluation of bacterial response and viability

An in vitro evaluation of fibrinogen and gelatin containing cryogels as dermal regeneration scaffolds

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An in vitro evaluation of fibrinogen and gelatin containing cryogels as dermal regeneration scaffolds

Content Provider	Royal Society of Chemistry (RSC)
Author	Mikhalovsky, S. V. Shevchenko, R. V. James, S. E. Tolhurst, B. A. Allan, I. U Jungvid, H. Illsley, M. Ivanov, A. Galaev, I. Y. Dainiak, M. B. James, S. L.
Copyright Year	2016
Abstract	Macroporous cryogels containing mixtures of two key components of the dermal extracellular matrix, fibrinogen and collagen-derived gelatin, were evaluated for use as dermal tissue regeneration scaffolds. The infiltration of human dermal fibroblasts into these matrices was quantitatively assessed in vitro using a combination of cell culture and confocal laser scanning microscopy. The extent of cellular infiltration, as measured by the number of cells per distance travelled versus time, was found to be positively correlated with the fibrinogen concentration of the cryogel scaffolds; a known potentiator of cell migration and angiogenesis within regenerating tissue. An analysis of the proteins expressed by infiltrating fibroblasts revealed that the cells that had migrated into the interior portion of the scaffolds expressed predominantly F-actin along their cytoplasmic stress fibres, whereas those present on the periphery of the scaffolds expressed predominantly α-smooth muscle actin, indicative of a nonmotile, myofibroblast phenotype associated with wound contraction. In conclusion, the cryogels produced in this study were found to be biocompatible and, by alteration of the fibrinogen content, could be rendered more amenable to cellular infiltration.
Starting Page	1007
Ending Page	1014
Page Count	8
File Format	HTM / HTML PDF
ISSN	20474830
Volume Number	4
Issue Number	6
Journal	Biomaterials Science
DOI	10.1039/c6bm00133e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	Cell culture Angiogenesis Phenotype Gelatin Actin Myofibroblast Fibrinogen Extracellular matrix Confocal microscopy Biocompatibility
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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