NDLI: A facile sensitive l-tyrosine electrochemical sensor based on a coupled CuO/Cu<sub>2</sub>O nanoparticles and multi-walled carbon nanotubes nanocomposite film

Content Provider	Royal Society of Chemistry (RSC)
Author	Wang, Miaomiao Mao, Xiaoqing Xia, Wenshui Li, Lei Gu, Wenxiu Wang, Yuru
Copyright Year	2015
Abstract	L-tyrosine in human urine is an essential biomarker for the early detection of various cancers. A facile electrochemical method for preparing a coupled copper oxide/cuprous oxide nanoparticles and multi-walled carbon nanotubes nanocomposite film modified glass carbon electrode (CuO/Cu2O/MWCNTs/GCE) via in situ growth is proposed for electrochemical sensing of L-tyrosine. The electrocatalytic activity of CuO/Cu2O/MWCNTs/GCE was investigated for L-tyrosine by cyclic voltammetry (CV), linear sweep voltammetry (LSV), electrochemical impedance spectroscopy (EIS) and chronoamperometry (CA), and the morphology and shape of the nanocomposite film were characterized by scanning electron microscope (SEM), energy-dispersive spectroscopy (EDS), transmission electron microscope (TEM) and X-ray powder diffraction (XRD). An irreversible oxidation peak for L-tyrosine at a potential of 0.645 V (vs. SCE) was observed in pH 8.0 of phosphate buffer solution at the CuO/Cu2O/MWCNTs/GCE electrode. The as-fabricated L-tyrosine sensor shows a fast response time (less than 2 s), a wide linear range 2 × 10−7–2 × 10−4 M, a high sensitivity of 1001 μA mM−1 cm−2 and a low detection limit of 9.6 × 10−9 M (at signal/noise = 3) in pH 8.0 phosphate buffer solution at 0.645 V. The nanocomposite film electrode has been successfully applied to determine L-tyrosine in human urine. It exhibits high electrocatalytic activity, satisfactory repeatability, stability, fast response and good selectivity against potentially interfering species, which suggests its potential for the development of a sensitive, selective, easy-operation and low-cost L-tyrosine sensor for practical routine analyses. The proposed new facile electrochemical growth method has the potential to expand the range of nanocomposite materials applied for the detection of various electroactive substances.
Starting Page	1313
Ending Page	1320
Page Count	8
File Format	HTM / HTML PDF
ISSN	17599660
Volume Number	7
Issue Number	4
Journal	Analytical Methods
DOI	10.1039/c4ay01925c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Copper(II) oxide Biomarker Powder diffraction Scanning electron microscope High-temperature superconductivity Cyclic voltammetry Linear sweep voltammetry X-ray crystallography Phosphate Copper(I) oxide Nanocomposite Chronoamperometry Electrical impedance Tyrosine Urine Spectroscopy Electrode Signal-to-noise ratio Buffer solution Carbon LSV Carbon nanotube Transmission electron microscopy Electrochemistry PH
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Engineering Chemical Engineering

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